Neuroscience 2000 Abstract
| Presentation Number: | 188.19 |
|---|---|
| Abstract Title: | Evaluation of diffuse brain injury with magnetic resonance imaging. |
| Authors: |
Suneson, A. S.*1
; Sköld, M.1
; Risling, M.1
; Lai, L. J.2
; Abo, M.2
; Chen, Z.2
; Bjelke, B.2
1Dept Human Sci, Natl Defense Res Establishment, S-172 90 Stockholm, Sweden 2Exp. MRI-unit, Karolinska Institutet, Stockholm, Sweden |
| Primary Theme and Topics |
J. Disorders of the Nervous System and Aging - 137. Trauma |
| Secondary Theme and Topics | B. Cell Biology<br />- 25. Staining, tracing, and imaging techniques |
| Session: |
188. Trauma: mechanisms and methodology Poster |
| Presentation Time: | Sunday, November 5, 2000 3:00 PM-4:00 PM |
| Location: | Hall G-J |
| Keywords: | TRAUMA, IMAGING, INJURY*, BLOOD-BRAIN |
Magnetic resonance imaging (MRI) provides detailed information about anatomical changes in the brain. However, the use of diagnostic routine MRI in patients with diffuse traumatic brain injury may underestimate the severity of injury. Diffusion-weighted imaging (DWI) has been useful in the diagnosis of stroke and ischaemia, where it has been reported to be a more sensitive indicator of the early pathological changes. In DWI and ADC (apparent diffusion coefficient) -mapping, the random movement of hydrogen atoms mainly in the water molecule is measured. These measurements yield information about structure tissue quality and pathophysiology. Disruptions in the blood–brain barrier seem to be associated with vasogenic edema and changes in the ADC values. In this study we have examined the effects on brain tissue of moderate air blast waves from explosions. A specially designed shock tube was used, in which anaesthetized rats were exposed to moderate air blast by the detonation of a charge consisting of the non-electric detonating cap with a 0,5 - 2 g PETN explosive at a distance of 1000 mm. The exposed animals were re-anaesthetized at 6, 24 and 48 hours as well as 1, 2 and 3 weeks and after the injury and examined by MRI. The T2 and DWI did not reveal any lesions in the brain of the exposed animals. Calculating the ADC values did show an alteration in the values over time in cortex cerebri and white matter, indicating a patological condition in the brains of the exposed animals. These data indicate that MRI when using T2 mapps and ADC maps may be useful diagnostic tool for the evaluation of diffuse brain injuries.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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