Neuroscience 2004 Abstract
| Presentation Number: | 141.2 |
|---|---|
| Abstract Title: | White-matter pathology in vascular dementia and Alzheimer's disease. |
| Authors: |
Kalaria, R. N.*1
; Polvikoski, T.1
; Slade, J. Y-.1
; Kenny, R.1
; Ince, P.1
; Perry, R.1
; Thomas, A.1
; Ballard, C. G.1
1CBV Path Group, WRC, Newcastle Gen Hosp, Newcastle Upon Tyne, United Kingdom |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Neurodegenerative Disorders -- Alzheimer's Disease: APP & Presenilin (other mechanisms) |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Neurodegenerative Disorders<br />-- Alzheimer's Disease: Cognitive function |
| Session: |
141. Dementia: Cognitive Deficits, Clinical Trials, and Pathology Slide |
| Presentation Time: | Sunday, October 24, 2004 8:15 AM-8:30 AM |
| Location: | San Diego Convention Center - Room 24A |
| Keywords: | Brain aging, Dementia, myelin, amyloid precursor protein |
Alzheimer's disease (AD) and vascular dementia (VaD) are two of the common dementias in the elderly. Imaging studies have demonstrated white matter changes of vascular etiology to occur in both disorders. While there have increased efforts to differentiate the white matter pathology by quantitative magnetic resonance imaging (MRI) methods in these disorders there is no clear concensus. We assessed white matter pathology in brains of prospectively assessed dementia patients who came to autopsy at our Institute. We examined the extent of white matter pathology by conventional and immunocytochemical methods including luxol fast blue for myelin, and amyloid beta precursor protein (APP) immunocytochemistry with 22C11 antibody. APP has recently been used to examine axonal injury in head trauma. Our results indicated APP reactive accumulation in the centrum semiovale region and along white matter tracts in the temporal lobe involving the hippocampal formation to be common. The highest reactivity was evident in tissue from VaD subjects as was in CADASIL cases compared to that from VaD-AD mixed and AD or dementia with Lewy bodies (DLB). Compared to coventional myelin stains APP immunoctochemstry was more sensitive to visualise subtle changes. We suggest that APP immunocytochemistry is a useful method to assess white matter pathology and correlation with MRI changes in different dementias.
Supported by the MRC (UK), Alzheimer's Research Trust (UK) and Alzheimer's Association (USA).
Supported by the MRC (UK), Alzheimer's Research Trust (UK) and Alzheimer's Association (USA).
Supported by MRC and ART (UK)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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