Neuroscience 2002 Abstract
| Presentation Number: | 183.1 |
|---|---|
| Abstract Title: | USE OF MRI TECHIQUES TO INVESTIGATE THE MATURATION OF THE TEMPORAL LOBES IN MACAQUES. |
| Authors: |
Machado, C. J.*1
; Babin, S. L.1
; Jackson, E. F.2
; Bachevlaier, J.1
1Dept of Neurobiol & Anat, Univ Texas Hlth Sci Ctr, Houston, TX 2Dept of Imaging Physics, Univ Texas M.D. Anderson Cancer Ctr, Houston, TX |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Cognitive learning and memory systems |
| Secondary Theme and Topics | Development<br />- Development of Sensory, Motor and Limbic Systems<br />-- Limbic system |
| Session: |
183. Animal cognition and behavior: cognitive learning and memory systems--nonspatial memory Poster |
| Presentation Time: | Sunday, November 3, 2002 1:00 PM-2:00 PM |
| Location: | Hall A2-B3 Q-22 |
| Keywords: | DEVELOPMENT, MONKEY, BRAIN IMAGING, COGNITION |
The purpose of this study was to investigate the volumetric development of medial temporal lobe structures in rhesus macaques using non-invasive magnetic resonance imaging (MRI) techniques. Four infant macaques (2 males, 2 females) were scanned in the coronal plane using a Fast Spin Echo Inversion Recovery protocol at 3-4 and 6 months of age. Three adult males (3 years old) were also scanned using identical procedures. We began our analysis by measuring the volume of the hippocampal formation (HF) using the Image J software. Surface area of the left and right HF were obtained from each image where the HF could be seen and were ultimately combined with image thickness (1.5 mm) to calculate the total HF volume for each subject. Data were analyzed using repeated measures ANCOVAs to adjust for total cerebral volume (3-4 months vs. 6 months comparison) or one-way ANOVAs (6 months vs. 3 years). The left and right HF volume did not differ at any age studied. However, the HF volume increased between 3-4 months and 6 months for females (p < .01) but not for males. When contrasted with the 3-year-old adults, 6-month-old infants had smaller HF volumes (p < .01). Thus, HF volume begins to mature earlier in females than males, but has not reached its full adult volume by 6 months of age. Overall, these neuroimaging data demonstrate that the postnatal expansion of the hippocampal formation in macaques continues at least past 6 months of age and parallel the protracted postnatal morphological changes seen previously by Seress et al. (1995).
Supported by MH58846, MH63577, HD 35471.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
Copyright © 2002-2025 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
