Neuroscience 2003 Abstract
| Presentation Number: | 121.1 |
|---|---|
| Abstract Title: | Evidence of magnetic resonance imaging T2-weighted abnormalities in the experimental diabetic mouse brain. |
| Authors: |
Toth, C. C.*1
; Tuor, U.1
; Brussee, V.1
; Foniok, T.1
; Hoyte, L.1
; Kaur, J.1
; Cunningham, S.1
; Barber, P.1
; Buchan, A.1
; Zochodne, D. W.1
1Dept. of Clin. Neurosci., Univ. of Calgary, Calgary, Canada |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Ischemia -- Cellular and molecular mechanisms |
| Session: |
121. Ischemia: Cell & Molecular Mechanisms III Slide |
| Presentation Time: | Sunday, November 9, 2003 8:00 AM-8:00 AM |
| Location: | Morial Convention Center - Room 255 |
| Keywords: | diabetes, magnetic resonance imaging, brain, white matter abnormalities |
Diabetes mellitus targets the human brain by contributing to the risk of stroke and contributing to white matter abnormalities, demonstrable using magnetic resonance imaging (MRI). In humans, these abnormalities have been associated with cognitive decline as well as subtle impairments in reasoning and coordination skills. We studied an in vivo model of streptozotocin-induced chronic long term (8 months) experimental diabetes in mice and littermate age- and sex-matched controls using MRI. MRI sequences obtained under general anesthesia included T1-weighted images, T2-weighted images and apparent diffusion coefficient (ADC) images. All MRI sequences were assessed blindly. As compared to controls, diabetic mouse brains demonstrated significant differences in T2 multi-echo image values at subcortical regions including striatum, thalamus, amygdala, substantia nigra, as well as hippocampus. Visually identified areas of T2 abnormalities were seen within regions such as the striatum, substantia nigra, and hippocampus. The long term experimental diabetic mouse model may be useful in further studies of behavior and cognition related to white matter changes due to diabetes mellitus.
(Supported by CIHR, CDA, AHFMR, and NRC).
(Supported by CIHR, CDA, AHFMR, and NRC).
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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