Neuroscience 2004 Abstract
| Presentation Number: | 114.6 |
|---|---|
| Abstract Title: | Decrease in left ventral anterior cingulate perfusion correlates with antidepressant response to partial sleep deprivation (PSD). |
| Authors: |
Clark, C. P.*1
; Brown, G. G.1
1Psychiatry, UCSD/VAMC, San Diego, CA |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Psychiatric Disorders -- Affective disorders--Pathology |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Brain Blood Flow, Metabolism, and Homeostasis<br />-- Functional Imaging |
| Session: |
114. Affective Disorders: Deficits and Risk Factors Poster |
| Presentation Time: | Saturday, October 23, 2004 2:00 PM-3:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # ZZ19 |
| Keywords: | depression, fmri, brain imaging, limbic |
Objective: To better understand mechanisms for the antidepressant effect of 1 night’s PSD in patients with current major depression. Hypothesis: Change in depressed patients’ ventral anterior cingulate perfusion will correlate with antidepressant response to PSD. Methods: 17 unmedicated unipolar outpatients (entry baseline 17-item Hamilton Depression Rating Scale (HDRS17) > 16, M/F 5/12, 42.8 + 9.7 years) & 8 controls (M/F 4/4, 35.0+9.5 years) received 3 nights (adaptation, baseline, & PSD, during which they had to remain awake beginning at 3 am)
polysomnography in the sleep laboratory. Approximately noon after the baseline & PSD nights, subjects received anatomical & perfusion magnetic resonance imaging (MRI) using pulsed arterial spin labeling, with baseline & PSD blocks in randomized counterbalanced order. Data were analyzed using Analysis of Functional NeuroImages (AFNI)2.56b. Stripped brains were segmented by fitting a 3-compartment Gaussian mixture model to the intensity histogram. Resulting gray matter masks were transformed into Talairach space and merged with Talairach daemon-based region of interest (ROI) templates to create standardized yet individualized ROI templates, which were used to mask perfusion data. Results: In patients, decrease in left ventral anterior cingulate perfusion from baseline to PSD scans correlated directly with the decrease in the modified HDRS17 (H17mod) (omitting sleep & weight loss items) between baseline & PSD conditions (1-tailed Pearson correlation coefficient .457, p <.033). No other ROIs showed correlations between change in H17mod & change in perfusion. Conclusion: These preliminary data—the first ever to utilize functional MRI—are consistent with previous PET (positron emission tomography) & SPECT (single photon emission computed tomography) findings of sleep deprivation & depression in linking decreased brain activity in this area with clinical improvement.
polysomnography in the sleep laboratory. Approximately noon after the baseline & PSD nights, subjects received anatomical & perfusion magnetic resonance imaging (MRI) using pulsed arterial spin labeling, with baseline & PSD blocks in randomized counterbalanced order. Data were analyzed using Analysis of Functional NeuroImages (AFNI)2.56b. Stripped brains were segmented by fitting a 3-compartment Gaussian mixture model to the intensity histogram. Resulting gray matter masks were transformed into Talairach space and merged with Talairach daemon-based region of interest (ROI) templates to create standardized yet individualized ROI templates, which were used to mask perfusion data. Results: In patients, decrease in left ventral anterior cingulate perfusion from baseline to PSD scans correlated directly with the decrease in the modified HDRS17 (H17mod) (omitting sleep & weight loss items) between baseline & PSD conditions (1-tailed Pearson correlation coefficient .457, p <.033). No other ROIs showed correlations between change in H17mod & change in perfusion. Conclusion: These preliminary data—the first ever to utilize functional MRI—are consistent with previous PET (positron emission tomography) & SPECT (single photon emission computed tomography) findings of sleep deprivation & depression in linking decreased brain activity in this area with clinical improvement.
Supported by 5K08MH01642
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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