Neuroscience 2001 Abstract
| Presentation Number: | 173.7 |
|---|---|
| Abstract Title: | DESENSITIZATION OF PONTINE NEUROTRANSMISSION OF TONIC ACTIVITY DURING HERING-BREUER REFLEX IN RAT. |
| Authors: |
Siniaia, M. S.*1
; Young, D. L.1
; Poon, C. S.1
1Div Hlth Sci & Technol, Harvard-MIT, Cambridge, MA |
| Primary Theme and Topics |
Autonomic, Limbic and Other Systems - Autonomic -- Respiratory regulation |
| Secondary Theme and Topics | Cognition and Behavior<br />- Animal Cognition and Behavior<br />-- Associative, nonassociative and skill learning & memory systems |
| Session: |
173. Autonomic: respiratory regulation Poster |
| Presentation Time: | Sunday, November 11, 2001 3:00 PM-4:00 PM |
| Location: | Exhibit Hall Z-3 |
| Keywords: | vagus, synaptic depression, habituation, learning and memory |
Our previous studies have shown that the Hering-Breuer (HB) reflex prolongation of expiratory duration exhibits a biphasic temporal adaptation pattern demonstrating habituation and desensitization in vagal and pontine pathways (Siniaia et al., J. Physiol. 523:479, 2000), which are similar to the on- and off-transients respectively of a second-order differentiator (Young, Siniaia & Poon, SFN 2001 Meeting). To elucidate the role of the pontine pathway in the adaptation of the HB reflex, we obtained extracellular recordings of pontine neuronal activity simultaneously with phrenic nerve recording during electrical vagal stimulation (1.5xT, 80 Hz, 1 min) in urethane-anesthetized, bi-vagotomized and artificially ventilated rats. Neurons with tonic and respiratory modulated activity were found within or near the parabrachialis (PB) and Kölliker-Fuse (KF) complex. Most tonic neurons in KF (n=11) were depressed during and/or shortly after vagal stimulation that elicited the characteristic biphasic adaptation of the HB reflex in the phrenic activity, whereas most tonic neurons in medial PB (n=22) were not affected. Results showed that vagal input induced short-term depression (STD) of tonic neurotransmission in KF. These findings support the hypothesis that vagal-induced desensitization of pontine input to the respiratory central pattern generator contributes to the biphasic adaptation of the HB reflex and its differentiator-like characteristic.
Supported by NIH grants 1R01HL60064 and 1F31MH12697
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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