Neuroscience 2004 Abstract
| Presentation Number: | 97.16 |
|---|---|
| Abstract Title: | Gradient echo MRI suggests a high prevalence of cerebral amyloid angiopathy hemorrhages in patients evaluated for dementia. |
| Authors: |
Atri, A.*1
; Lin, J. M.1
; Yap, L.1
; Dickerson, B. C.1
; Growdon, J. H.1
; Greenberg, S. M.1
1Dept. of Neurol., Massachusetts Gen. Hosp. & Harvard Med. Sch., Boston, MA |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Neurodegenerative Disorders -- Other |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Aging<br />-- Other |
| Session: |
97. Other Alzheimers Mechanisms Poster |
| Presentation Time: | Saturday, October 23, 2004 4:00 PM-5:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # PP26 |
| Keywords: | Amyloid, Dementia, Alzheimer, Hemorrhage |
OBJECTIVE: To assess the prevalence of microhemorrhages (MHs) possibly related to cerebral amyloid angiopathy (CAA) among consecutive patients undergoing MR imaging in a memory disorders unit. BACKGROUND: The estimated prevalence of neuropathological CAA and CAA-related hemorrhages in Alzheimer's disease (AD) is 80-98% and 5-7% respectively. While CAA cannot be directly detected during life, MHs characteristic of CAA can be sensitively imaged by gradient-echo (GE) MRI. The presence of multiple strictly lobar hemorrhages without other cause (Probable CAA) is a specific marker for advanced CAA. DESIGN/METHOD: All patients age 55 or greater from the Massachusetts Alzheimer's Disease Research Center (MADRC) Patient Registry database who underwent initial dementia evaluation with GE MRI at our center between January 2001 and September 2003 were retrospectively reviewed. RESULTS: Of 61 eligible patients, 21 (34%) had hypointensities on GE MRI, 7 (11%) meeting criteria for Probable CAA, and an additional 2 showed a single lobar microhemorrhage (Possible CAA). Other GE hypointensities were due to mineralizations (n = 8), meningiomas (n = 2), hypertensive hemorrhage (n = 1), and cavernoma (n = 1). There were no gender differences, but patients with lobar MHs were older that those without (80.0 vs 74.2 years; p = 0.05). CONCLUSIONS: The prevalence of CAA-related MHs in patients evaluated for dementia may be higher than predicted from autopsy series. These data raise the possibility that CAA may be a relatively common contributor to cognitive impairment and highlight the potential utility of GE MRI in the diagnostic evaluation of dementia.
Supported by MADRC (NIA5 P50AG05134), Harvard-MIT Pfizer CITP
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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