Neuroscience 2003 Abstract
| Presentation Number: | 90.7 |
|---|---|
| Abstract Title: | Interactions of the prefrontal cortex and medial temporal lobe in delayed non-match to sample (DNMS). |
| Authors: |
Welke, L. A.*1
; Moore, T. L.1
; Killiany, R. J.1
; Rosene, D. L.1
; Moss, M. B.1
1Dept. Anat. & Neurobiol, Boston Univ. Sch. Med, Boston, MA |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Cognitive learning and memory systems |
| Session: |
90. Animal Cognition and Behavior: Prefrontal Cortex I Poster |
| Presentation Time: | Saturday, November 8, 2003 3:00 PM-4:00 PM |
| Location: | Morial Convention Center - Hall F-I, Board # W6 |
| Keywords: | LEARNING AND MEMORY, COGNITION, MONKEY, LESION |
We previously reported (SFN 2001) that monkeys with bilateral lesions of the prefrontal cortex (PFC) were more impaired, relative to normals, than monkeys with bilateral lesions of the hippocampus (HF) on postoperative acquisition of the DNMS task. Moreover, on the 10 minute delay of this task, monkeys with PFC lesions were more impaired relative to normals than HF animals. To test the hypothesis of a functional interaction between HF and PFC, a group of 5 animals received lesions of the medial temporal lobe (hippocampus and parahippocampal gyrus: HF+) in one hemisphere and the dorsal prefrontal cortex (areas 46 and 9: PFC) in the other plus a commissural split (callosum and anterior commissure) to disconnect the intact HF and PFC (group CFHS). As a control, a group of 4 animals was prepared with HF+ and PFC lesions in the same hemisphere along with a commissural split leaving the HF and PFC interconnected in the other hemisphere (group IFHS). Both groups were tested on DNMS acquisition and delays. The cross lesion group (CFHS) was impaired relative to the ipsilateral lesion group (IFHS) on both DNMS acquisition (p=0.036) and the 10 min delay condition (0.028). This confirms that information must be shared between the hippocampus and prefrontal cortex for efficient performance on all conditions of the DNMS task. In addition, an analysis of the pattern of errors during acquisition revealed that both the CFHS and IFHS groups initially had a high incidence of positional errors that steadily decreased as they progressed to learning criterion. This profile is consistent with that seen in our previous study with PFC lesions, and suggests that this task not only requires interactions between the hippocampus and prefrontal cortex but also between the two prefrontal cortices. Taken together, this data support the hypothesis of a significant interaction of the hippocampus and prefrontal cortex in both learning and memory.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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