Neuroscience 2005 Abstract
| Presentation Number: | 114.13 |
|---|---|
| Abstract Title: | Differential induction of δFosB by various drugs of abuse. |
| Authors: |
Perrotti, L. I.*1
; Elmore, R. G.1
; Selley, D. E.2
; Sim-Selley, L.2
; Bachtell, R.1
; Winstanley, C. A.1
; Self, D. W.1
; Nestler, E. J.1
1Dept. Psychiatry, Univ. of Texas Southwestern Med. Ctr., Dallas, TX 2VA, 5323 Harry Hines Blvd, 75390-9070, |
| Primary Theme and Topics |
Disorders of the Nervous System - Addiction and Drugs of Abuse -- Neurobiology of reward |
| Secondary Theme and Topics | Disorders of the Nervous System<br />- Addiction and Drugs of Abuse<br />-- Addiction: Neurobiology |
| Session: |
114. Neurobiology of Reward Poster |
| Presentation Time: | Saturday, November 12, 2005 1:00 PM-2:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # VV88 |
| Keywords: | nucleus accumbens, immunohistochemistry, stereology, dorsal striatum |
The transcription factor ΔFosB accumulates and persists in brain in response to chronic stimulation. This accumulation after chronic exposure to drugs of abuse has been demonstrated previously by Western blot in several brain regions, including the nucleus accumbens, dorsal striatum, amygdala, and frontal cortex. In the present study, we used immunohistochemistry to define with greater anatomical precision the induction of ΔFosB after chronic drug treatment. We used two antibodies; one that recognizes both FosB and ΔFosB, and another that recognizes FosB only. Animals received one of five chronic drug treatments or the respective control: cocaine, self-administered cocaine, morphine, Δ9-THC, or ethanol. Each drug treatment increased the number of ΔFosB immunoreactive cells in a region-specific manner in brain. All treatments induced ΔFosB in the nucleus accumbens, although some differences were seen. For example, ΔFosB induction occurred in both the core and shell after cocaine and the other treatments, but was seen only in the shell subregion after morphine treatment. Similarly, each of the drugs, except Δ9-THC, induced ΔFosB in the dorsal striatum. Additionally, as previously reported, only cocaine induced ΔFosB expression in the posterior VTA. Experiments are underway to complete the mapping for these five drug treatments in other reward-relevant brain regions and to investigate the cellular profile of the ΔFosB positive cells. We will then be able to characterize brain regions and cell populations exhibiting this effect and begin to understand the functional consequences of the regional specificity of ΔFosB induction by drugs of abuse.
Supported by NIDA
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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