Neuroscience 2004 Abstract
| Presentation Number: | 82.8 |
|---|---|
| Abstract Title: | Prefrontal cortex and medial temporal lobe interactions are important for recognition memory but not executive system function in the non-human primate. |
| Authors: |
Welke, L. A.*1
; Killiany, R. J.1
; Moore, T. L.1
; Rosene, D. L.1
; Moss, M. B.1
1Dept Anat & Neurobiol, Boston Univ Sch Med, Boston, MA |
| Primary Theme and Topics |
Cognition and Behavior - Human and Animal Cognition and Behavior -- Cognitive learning and memory systems |
| Secondary Theme and Topics | Cognition and Behavior<br />- Human and Animal Cognition and Behavior<br />-- Executive function |
| Session: |
82. Cognitive Learning and Memory: Primates Poster |
| Presentation Time: | Saturday, October 23, 2004 4:00 PM-5:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # GG10 |
| Keywords: | hippocampus, monkey |
To assess functional interaction between the medial temporal lobe (MTL) and prefrontal cortex (PFC), 5 animals received lesions of the MTL (hippocampus and parahippocampal gyrus: HF+) in one hemisphere and the prefrontal cortex (areas 46 and 9) in the other plus a commissural split (callosum and anterior commissure) to disconnect the intact MTL and PFC (group CFHS). As a surgical control, 4 animals were given HF+ and PFC lesions in the same hemisphere along with a commissural split leaving the MTL and PFC intact and interconnected in the other hemisphere (group IFHS). We previously reported (SFN 2003) that monkeys in group CFHS were impaired on Delayed Non Match to Sample Acquisition and Delays relative to the control group (IFHS). To further explore the interaction between PFC and MTL we administered the Delayed Recognition Span Task (DRST), assessing working memory performance with increasing memory load and the Conceptual Set Shifting Task (CSST), a test analogous to the human Wisconsin Card Sorting Test that tests executive system function (abstraction and set shifting). The CFHS group were significantly impaired on all conditions of the DRST (spatial [p=0.008], object [p=0.003] and spatial redo [p=0.018]) compared to the IFHS group. On the CSST, there was no significant difference between groups in abstracting the initial concept (Red [p=0.31]), or on any of the subsequent shift conditions. These data support the hypothesis that the interaction of the medial temporal lobe and prefrontal cortex is important for performance on tests of rule learning recognition memory and working memory tasks such as the DRST and DNMS. Absence of impairment on CSST suggests that the remaining intact prefrontal cortex may be able to support executive system functions alone, or that the prefrontal cortex and medial temporal lobe contribute independently.
Supported by NSF award IBN-9982889
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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