Neuroscience 2005 Abstract
| Presentation Number: | 109.4 |
|---|---|
| Abstract Title: | Psychological and physiological distress in posttraumatic stress disorder: a functional MRI study. |
| Authors: |
Tuescher, O.*1
; Protopopescu, X.1,2
; Pan, H.1
; Zimmerman, D.1
; Engelien, A.1,3
; Goldstein, M.1
; Klein, C.
; Epstein, J.1
; Yang, Y.1
; Cloitre, M.
; Gorman, J.
; Phelps, E.
; LeDoux, J.
; Stern, E.1
; Silbersweig, D.1
1Weill Med. Col. of Cornell Univ., New York, NY 2NY, 1300 York Ave, 10021, 3USA, 1300 York Ave, 10021, |
| Primary Theme and Topics |
Disorders of the Nervous System - Cognitive, Emotional and Behavioral State Disorders -- Anxiety disorders |
| Secondary Theme and Topics | Cognition and Behavior<br />- Human Cognition, Behavior, and Anatomy<br />-- Emotion |
| Session: |
109. Anxiety Disorders: Neural Mechanisms and Treatment Poster |
| Presentation Time: | Saturday, November 12, 2005 4:00 PM-5:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # VV12 |
| Keywords: | ANXIETY, EMOTION, NEUROIMAGING, HUMAN |
This study examined the relation of fronto-limbic functional abnormalities to particular components of PTSD symptomology, in this case the symptoms of psychological and physiological distress. Subjects with DSM-IV diagnosis of PTSD, associated with sexual/physical assault, were studied using two complementary fMRI activation probes, an emotional word paradigm, and an instructed fear conditioning paradigm. Symptoms were evaluated by the Clinician-Administered PTSD Scale (CAPS). Significant activations at p<0.05 (SVC) in a priori regions of interest are reported. As expected, activity changes in mesotemporal and ventro-medial prefrontal brain regions correlated more closely with the relevant combinations of probes and clinical symptoms. With the linguistic, top-down emotional word paradigm, the CAPS score for psychological distress (B4) was positively correlated with right more than left amygdala activity, and negatively with left posterior OFC, left ventral striatum and anterior insula activity. With the non-verbal, bottom-up instructed fear paradigm physiological distress (B5) was correlated with left amygdala increased activity and vmPFC decreased activity. When thresholds were lowered to uncorrected levels across both paradigms and both scores, activity patterns converged on the paradigm level, illustrating that the correlations with the disease scores augmented the underlying paradigm evoked activity changes in a region specific way. These findings illustrate the utility of complementary paradigms for probing the neural substrates of specific psychological and physiological PTSD symptoms.
Supported by NIMH Grant P50 MH58911
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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