Neuroscience 2005 Abstract
| Presentation Number: | 91.3 |
|---|---|
| Abstract Title: | Distinguishing Alzheimer's disease and frontotemporal dementia using PET imaging with Pittsburgh compound-B. |
| Authors: |
Sun, F. T.*1
; Baker, S. L.2
; O'Neil, J. P.2
; Miller, B. L.3
; Rosen, H. J.3
; Jagust, W. J.1,2
1Helen Wills Neuroscience Inst., Univ. of California, Berkeley, CA 2CA, 118 Barker Hall, 94720, 3USA, 118 Barker Hall, 94720, |
| Primary Theme and Topics |
Disorders of the Nervous System - Aging -- Molecular studies |
| Session: |
91. Aging: Molecular Studies I Poster |
| Presentation Time: | Saturday, November 12, 2005 3:00 PM-4:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # QQ16 |
| Keywords: | AMYLOID, DEMENTIA, ALZHEIMER, FRONTOTEMPORAL |
The development of quantitative in vivo measures for differentiating Alzheimer's disease (AD), from other forms of dementia, such as Frontotemporal dementia (FTD), is of great clinical significance. Correct differential diagnoses of dementias are increasingly important as new treatments become available. AD neuropathology is characterized by the presence extracellular amyloid-β peptide fibrils and intracellular neurofibrillary tangles. While neurofibrillary changes may be present in other forms of dementia, for example frontotemporal dementia with parkinsonism (FTDP), Aβ accumulation appears to be specific to AD. PET imaging with Pittsburgh compound-B (PIB) has been shown to be effective in identifying amyloid deposition in mild cognitive impairment (Klunk et al., SFN 2003) and Alzheimer’s patients (Klunk et al., 2004). In this study, we compare the uptake of PIB in AD, FTD, and healthy older individuals. Patients were recruited and evaluated at the USCF memory and aging center, and the AD diagnosis was based on the NINCDS-ADRDA criteria. We examined PIB retention by calculating the voxel-wise distribution volume ratio (DVR), as well as by examining the averaged DVR of specific cortical and subcortical regions of interest (ROIs), including the frontal cortex, parietal cortex, caudate, and white matter. DVR values were obtained using a graphical analysis technique for reversible tracers (Logan et al., 1990). Preliminary results indicate that PIB uptake in cortical regions is increased in AD patients compared to healthy older controls, while the uptake pattern in FTD patients resembles the pattern seen in controls. This suggests that PIB may be a useful measure for distinguishing AD from other types of dementias, which are not characterized by a marked increase in Aβ plaque formation.
Supported by DOE
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
Copyright © 2005-2026 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
