Neuroscience 2001 Abstract
| Presentation Number: | 111.9 |
|---|---|
| Abstract Title: | GRAY MATTER REDUCTION IN BIPOLAR PATIENTS WITH MRI AND VOXEL-BASED MORPHOMETRY: PRELIMINARY RESULTS. |
| Authors: |
Sassi, R. B.*1
; Nicoletti, M.1
; Brambilla, P.1
; Harenski, K.1
; Mallinger, A. G.1
; Frank, E.1
; Kupfer, D. J.1
; Keshavan, M. S.1
; Soares, J. C.1
1Psychiatry, Univ Pittsburgh Sch Med, Pittsburgh, PA |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Psychiatric Disorders -- Affective Disorders |
| Session: |
111. Psychiatric disorders: mood disorders--human studies I Poster |
| Presentation Time: | Sunday, November 11, 2001 8:00 AM-9:00 AM |
| Location: | Exhibit Hall AAA-58 |
| Keywords: | mood disorders, brain imaging, neuroimaging, bipolar disorder |
Brain imaging studies have suggested regional reduction in gray matter content in bipolar patients in key anatomical regions involved in mood regulation. Most studies have utilized region-of-interest based methodologies, in which a particular brain structure is chosen a priori, traced, and then compared among different groups. As a different approach, voxel-based morphometry can potentially identify gray matter changes across the whole brain. We examined structural T1-weighted 1.5 T MR images of 26 bipolar disorder patients (age±S.D.= 35.2±10.4 years) and 39 healthy subjects (age±S.D.= 36.6±9.7 years). SPM99 was utilized to normalize the images to the MNI brain template, segment, smooth, and generate a statistical map of the differences between the groups, with age as covariate. Statistical significance was set at p<0.01 (voxel-level, uncorrected). Compared with the healthy control group, the bipolar subjects presented decreased gray matter density in an area in the left temporal lobe encompassing the limbic lobe, parahippocampal gyrus and superior temporal gyrus (Z=3.9), right inferior temporal gyrus and uncus (Z=3.6), superior frontal gyrus in the Brodmann areas 9 (Z=3.5) and 11 (Z=3.2), and left and right cerebellum (Z=3.6 and 2.7, respectively). Although preliminary, these results point in the same direction as previous region-of-interest based studies, and suggest that voxel-based morphometry is a useful tool to examine brain anatomical abnormalities in mood disorder patients.
Supported by MH 01736, MH 29618, and MH 30915, the Stanley Foundation, NARSAD and CAPES Foundation (Brazil).
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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