Neuroscience 2002 Abstract
| Presentation Number: | 114.9 |
|---|---|
| Abstract Title: | The Inhibitory Component of Pain-Induced Cerebral Activation: An Event-Related fMRI Study. |
| Authors: |
Kurata, J.*1
; Thulborn, K. R.2
; Firestone, L. L.1
1Anesthesiology, University of Pittsburgh, Pittsburgh, PA 2Radiology, University of Illinois at Chicago, Chicago, IL |
| Primary Theme and Topics |
Sensory Systems - Pain -- Functional imaging, psychophysics, human behavior |
| Session: |
114. Pain pathways Slide |
| Presentation Time: | Sunday, November 3, 2002 3:00 PM-3:15 PM |
| Location: | Room 203A |
| Keywords: | PAIN, SACCADE, FMRI |
Pain-related cerebral activation in functional magnetic resonance imaging (fMRI) shows less consistent blood oxygenation level-dependent (BOLD) signals that decay earlier than in conventional task-related activation. It may result from pain's inhibitory effects on the global cerebral hemodynamics and activation of the descending pain inhibitory systems. Using event-related fMRI, we have examined whether pain affects cerebral activation by a saccade task through such inhibitory mechanisms. Six right-handed volunteers underwent whole-brain echo-planar imaging on a 3 T MRI scanner, while they received thermal pain stimulus at 50°C on the right forearm (P; n = 6); performed a visually guided saccade task (V; n = 6); and went through simultaneous P and V (PV; n = 5). Each consisted of 60 cycles of 1-s stimulus followed by 14-s rest condition. BOLD signal time courses were analyzed at local maxima of averaged functional activation maps. P activated the bilateral secondary somatosensory cortex (S2). V activated the posterior, supplementary, frontal eye fields, and visual areas. PV enhanced the S2 activation and activated additional areas including the bilateral premotor area, right insula, anterior, and posterior cingulate cortices. In contrast, V-related activation was attenuated in PV. The paradoxical interactions between P- and V-related activation may be a result of the global reduction of cerebral blood flow by pain and its partial reversal by the concomitant saccade task, or to the effects of attention and expectation.
Supported by The International Anesthesia Research Society and the National Instututes of Health (PO1 NS35949)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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