Neuroscience 2005 Abstract
| Presentation Number: | 87.14 |
|---|---|
| Abstract Title: | Compensatory mechanisms on MPTP-treated monkeys with recovery of parkinsonian motor symptoms: II. Biochemical approach by microdialysis in the striatum. |
| Authors: |
Boulet, S.*1
; Mounayar, S.2
; Bertrand, A.1
; Poupard, A.1
; Jan, C.2
; Pessiglione, M.2
; Hirsch, E. C.2
; Francois, C.2
; Feger, J.2
; Savasta, M.1
; Tremblay, L.2
1UFR Biology, INSERM U704, Grenoble, France 2France, 2280 Rue de la Piscine, Bat B, BP53, 38000, |
| Primary Theme and Topics |
Disorders of the Nervous System - Neurodegenerative and Movement Disorders -- Parkinson's disease: Models |
| Secondary Theme and Topics | Sensory and Motor Systems<br />- Basal Ganglia<br />-- Neuromodulatory cascades and function |
| Session: |
87. Parkinson's Disease Models: MPTP I Poster |
| Presentation Time: | Saturday, November 12, 2005 2:00 PM-3:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # OO7 |
| Keywords: | PRIMATE, BASAL GANGLIA, NEURODEGENERATION, PLASTICITY |
Patients with Parkinson’s disease (PD) express motor symptoms only after 60-80% depletion of striatal dopamine (DA). Before this symptomatic phasis, the progressive loss of the dopaminergic innervation is likely associated with adaptive biochemical modifications within the striatum (the main target of this projection). These modifications could be involved in delaying the appearance of motor symptoms. We propose that our MPTP monkey model, based on a progressive intoxication (injection of 0,4 mg/kg, every 4 or 5 days; see Mounayar, et al. SfN abstract 2005), is suitable to study the compensatory mechanisms which underlie the presymptomatic stage of PD. Microdialysis has been performed in the same awake animal during normal state, during full expression of motor symptoms induced by MPTP and after recovery of these symptoms in order to correlate motor deficits and their recovery with changes of striatal neurotransmitter levels. We focussed our study on DA and its metabolites (DOPAC, HVA), GABA, Glutamate (Glu) and serotonin (5-HT) levels in two striatal territories: limbic and sensorimotor. Preliminary results, obtained with 3 monkeys, show important neurochemical variations according to the different states studied. These variations concern all neurotransmitters (DA, Glu, GABA, 5-HT) but mainly in the sensorimotor territory of the striatum. In the limbic territory only a changes of DA level were detected after recovery of motor symptoms. These data suggest that slight DA increase in sensorimotor and/or limbic territory underlie the recovery of motor symptoms in our monkey model. The same DA changes could play an important role in the compensatory mechanisms involved in the presymptomatic stage of PD.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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