Neuroscience 2000 Abstract
| Presentation Number: | 110.6 |
|---|---|
| Abstract Title: | Regional brain atrophy in cognitively normal apolipoprotein E ε4 homozygotes evaluated by voxel-based MRI morphometry. |
| Authors: |
Alexander, G. E.*1
; Chen, K.3
; Reiman, E. M.3
; Caselli, R.2
; Bandy, D.3
; Frost, J.3
1Psychology Dept., Arizona State Univ., Tempe, AZ 2Neurology Dept., Mayo Clinic Scottsdale, Scottsdale, AZ 3Good Samaritan PET Center, Banner Health, Phoenix, AZ |
| Primary Theme and Topics |
J. Disorders of the Nervous System and Aging - 130. Degenerative disease: Alzheimer's-other |
| Secondary Theme and Topics | J. Disorders of the Nervous System and Aging<br />- 128. Degenerative disease: Alzheimer's-cognitive function |
| Session: |
110. Degenerative disease: Alzheimer's--other: imaging and others Slide |
| Presentation Time: | Sunday, November 5, 2000 2:15 PM-2:30 PM |
| Location: | Room 293 |
| Keywords: | Alzheimer, Human, Neuroimaging, Morphology |
Posterior cingulate, parietal, temporal, and prefrontal cortices have been implicated as brain regions affected in the early stages of Alzheimer's disease (AD). To evaluate whether atrophy in these brain regions occurs prior to the onset of cognitive symptoms in individuals at risk for AD, we compared 11 cognitively normal ε4 homozygotes with a reported family history of AD (mean ±SD age = 55±4 yr; 3M, 8F) to 22 gender-, age-, and educationally-matched ε4 non-carriers (mean±SD age = 56±5 yr; 6M, 16F) using voxel-based MRI morphometry. T1-weighted, volumetric MRI's were acquired using a 1.5 T scanner. SPM99 was used to transform them into the coordinates of a standard brain atlas, correct them for inhomogeneities, segment them for gray matter, smooth them, and create a statistical brain map of significant group differences in gray matter density. Significance was taken at p ≤ 0.005 (uncorrected for multiple comparisons) for hypothesized regional effects. In comparison with the ε4 noncarriers, the ε4 homozygous group had significantly lower gray matter densities in the vicinity of right posterior cingulate cortex (z = 3.43), a right hippocampal region (z = 3.84), and left parahippocampal and lingual gyri (z = 3.16). This study provides gross morphometric support for the early involvement of posterior cingulate and medial temporal lobe regions in AD. If, as postulated, the abnormalities in gray matter density are progressive, voxel-based MRI morphometry could help track the progression of AD prior to the onset and during the course of Alzheimer's dementia.
Supported by NIH Grant MH57899-01A1 and Arizona Alzheimer's Disease Research Center
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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