Neuroscience 2000 Abstract
| Presentation Number: | 110.2 |
|---|---|
| Abstract Title: | MRI microscopy of human aged and Alzheimer's disease cerebral samples. |
| Authors: |
Dhenain, M.*1,2
; Privat, N.3
; Duyckaerts, C.3
; Jacobs, R. E.1
1Caltech, Pasadena, CA 2Institut Curie, Orsay, France 3Hopital de la Salpêtrière, Paris, France |
| Primary Theme and Topics |
J. Disorders of the Nervous System and Aging - 130. Degenerative disease: Alzheimer's-other |
| Secondary Theme and Topics | J. Disorders of the Nervous System and Aging<br />- 148. Aging |
| Session: |
110. Degenerative disease: Alzheimer's--other: imaging and others Slide |
| Presentation Time: | Sunday, November 5, 2000 1:15 PM-1:30 PM |
| Location: | Room 293 |
| Keywords: | Alzheimer, Aging, MRI, Amyloid |
Previous studies suggest that high resolution MRI can detect amyloid deposits [Benveniste H, 1999]. In this study we used a 11.7T imaging system to record 3-D T2*-weighted gradient echo images at 11.7 µm per voxel of formalin-fixed T1 temporal horn specimens from 3 aged non demented subjects and 3 Alzheimer's disease subjects. Tissue encompassed cerebral cortex and white matter. The samples were then stained for amyloid (Aß) deposits and for iron deposits. In both Alzheimer diseased and control cerebral cortices, hypo-intense spots and halo-like structures were clearly visible in MR images. 3D visualization of the images and comparison of MR images with neuropathology revealed that some of the hypo-intense structures were blood vessels. Due to susceptibility effects caused by residual iron, the blood vessels appeared larger in MR images than in neuropathological slices. In some Alzheimer samples, spots in the MR images had a geographical pattern similar to the pattern of amyloid deposits. However, in other samples, numerous amyloid deposits that were visible in neuropathological slides were not visible by MRI and no susceptibility effects were noted. In conclusion, amyloid deposits were detected by MRI in some sample but not in all. With 2D visualization blood vessels and amyloid plaques have a similar appearance in MR image. Moreover, susceptibility effects associated with senile plaques (if present) are significantly less marked than those associated with blood vessels.
Supported by The Bettencourt-Schueller foundation, the France-Alzheimer Association, the National Center for Research Resources, and the Human Brain Project with contributions from NIMH & NIDA.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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