Neuroscience 2000 Abstract
| Presentation Number: | 110.1 |
|---|---|
| Abstract Title: | MRI studies of corpus callosum and hippocampus atrophy as independent markers of structural disease progression. |
| Authors: |
Hampel, H.*1,2
; Teipel, S. J.1,2
; Bayer, W.1
; Alexander, G. E.2
; Schapiro, M. B.2
; Möller, H. J.2
; Rapoport, S. I.2
1Dept Psychiat/Geriatric Psychiat Branch, Ludwig-Maximilian University, 80336 Munich, Germany 2Laboratory of Neurosciences, National Institute on Aging, National Instituites of Health , 20982 Bethesda, MD |
| Primary Theme and Topics |
J. Disorders of the Nervous System and Aging - 130. Degenerative disease: Alzheimer's-other |
| Secondary Theme and Topics | H. Other Systems of the CNS<br />- 99. Association cortex and thalamocortical relations |
| Session: |
110. Degenerative disease: Alzheimer's--other: imaging and others Slide |
| Presentation Time: | Sunday, November 5, 2000 1:00 PM-1:15 PM |
| Location: | Room 293 |
| Keywords: | ALZHEIMER, IMAGING, HIPPOCAMPUS*, COGNITIVE* |
Postmortem studies indicate a temporal sequence of primary allocortical and secondary neocortical degeneration during Alzheimer disease (AD) progression. Hippocampus (HC) atrophy correlates with allocortical neuronal degeneration and atrophy of the corpus callosum (CC) reflects loss of intracortical projecting pyramidal neurons in neocortex. First, we wanted to determine the temporal sequence and rate of degeneration of HC and CC in AD. Second, to answer the question, whether rates of atrophy were correlated with rates of cognitive decline and third, whether both markers could be proposed as potential morphological parameters for mapping drug effects on brain structure in longitudinally studied AD patients and healthy control subjects. MRI-derived measures of CC and HC were compared between 27 clinically diagnosed AD patients and 28 age- and gender-matched healthy control subjects. Rates of CC and HC atrophy were determined in 21 AD patients and 10 control subjects studied longitudinally. We found mean relative rates of atrophy per year for CC (6.9 %) and HC (12.2 %) in AD which were significantly larger than rates of atrophy of 0.2 % - 0.9 % per year in healthy controls. HC atrophy preceded CC atrophy in mild AD. Rates of CC, but not of HC atrophy, were correlated with the progression of cognitive impairment in AD patients. We suggest that HC and CC are independent markers of allocortical and neocortical neurodegeneration and may be applied in studies mapping disease progression.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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