Neuroscience 2004 Abstract
| Presentation Number: | 1011.4 |
|---|---|
| Abstract Title: | Color fractional anisotropy MAPs in neurodegenerative diseases a preliminary report. |
| Authors: |
Yoshikawa, K.*1
; Yamada, K.2
; Nishimura, T.2
; Nakagawa, M.1
1Dept. Neurol., Kyoto Prefectural Univ. Med., Kyoto 602-8566, Japan 2Dept. Radiol., Kyoto Prefectural Univ. Med., Kyoto 602-8566, Japan |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Neurodegenerative Disorders -- Parkinson's Disease: Other |
| Secondary Theme and Topics | Techniques in Neuroscience<br />- Staining, tracing and imaging techniques |
| Session: |
1011. Parkinson's Disease: Clinical Manifestations and Therapeutic Trials Poster |
| Presentation Time: | Wednesday, October 27, 2004 4:00 PM-5:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # TT11 |
| Keywords: | MRI, IMAGING, PARKINSON, DEGENERATION |
OBJECTIVES: Fractional anisotropy value (FA) analysis in diffusion tensor magnetic resonance imaging in various neurological diseases requires presumable allocation of regions-of-interest (ROIs). We proposed a color FA mapping that enables visual estimation without ROI allocation. SUBJECTS and METHODS: Eight patients with Parkinson's disease (PD), six age-matched patients with progressive supranuclear palsy (PSP), and eight age-matched normal subjects underwent diffusion-weighted MRI using 1.5T clinical imager. Derived FA maps of the brains were normalized, and converted into 32-step color FA maps. RESULT: Averaged color FA map of parkinsonian patients showed decrease in not only hypothalamus but also white matters of frontal lobes, while averaged map of PSP patients revealed profound decrease in FA values of most parts of the white matter, compared with those of normal subjects. We confirmed these changes by subtraction method and direct comparison of FA values. DISCUSSION: An overview of FA change derived from color FA map followed by minute comparison of FA in ROIs allocated after the global survey may be a new strategy for making FA analysis more effective in either exploratory studies for various neurological diseases, or in clinical use.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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