Neuroscience 2004 Abstract
| Presentation Number: | 1009.9 |
|---|---|
| Abstract Title: | Pretreatment with ondansetron or delta-9-tetrahydrocannabinol interferes with the establishment of lithium-induced taste avoidance in the house musk shrew (Suncus murinus). |
| Authors: |
Kwiatkowska, M.*1
; Parker, L. A.1
1Dept Psychology, Wilfrid Laurier Univ, Waterloo, Canada |
| Primary Theme and Topics |
Cognition and Behavior - Human and Animal Cognition and Behavior -- Learning & memory: Pharmacology |
| Secondary Theme and Topics | Cognition and Behavior<br />- Motivation and Emotion |
| Session: |
1009. Learning and Memory Pharmacology III Poster |
| Presentation Time: | Wednesday, October 27, 2004 1:00 PM-2:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # SS14 |
| Keywords: | taste aversion, cannabinoids, serotonin, learning |
Recent evidence suggests that toxin-induced taste avoidance in the non-emetic rat is not mediated by conditioned sickness. However, it is possible that toxin-induced taste avoidance in an emetic species is mediated by conditioned sickness. The present experiments evaluated the potential of the anti-emetic agents, ondansetron (OND) and delta-9-tetrahydrocannabinol (THC) to interfere with lithium (LiCl)-induced taste avoidance in the house musk shrew (Suncus murinus). In Experiment 1, shrews were pretreated with OND (1.5 mg/kg) or Saline 30 min prior to drinking 0.1% saccharin solution then they were injected with LiCl (390 mg/kg) or saline. When assessed by a two-bottle test over a 12 hr period, but not a one bottle test, the shrews displayed a LiCl-induced saccharin avoidance that was prevented by pretreatment with OND. The relatively weak effects may have been due to floor effects in consumption of saccharin solution; therefore a highly preferred 32% sucrose solution was used in another experiment. In Experiment 2 shrews were pretreated with OND, THC (5-10 mg/kg) or Saline 30 min prior to sucrose solution exposure. With the more highly preferred sucrose solution, OND and THC interfered with the establishment of LiCl-induced taste avoidance. These results suggest that taste avoidance in the shrew, unlike the rat, is motivated by conditioned sickness.
Supported by Canadian Institute of Health Research (CIHR) granted to Dr. Linda Parker
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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