Neuroscience 2000 Abstract
| Presentation Number: | 103.7 |
|---|---|
| Abstract Title: | Acute marijuana effects on rCBF and cognition. |
| Authors: |
O'Leary, D. S.*1
; Block, R. I.
; Flaum, M.
; Schultz, S. K.
; Boles Ponto, L. L.
; Watkins, G. L.
; Hichwa, R. D.
1Psychiatry, U of I Hospitals, Iowa City, IA |
| Primary Theme and Topics |
I. Neural Basis of Behavior - 120. Behavioral pharmacology |
| Secondary Theme and Topics | D. Neurotransmitters, Modulators, Transporters, and Receptors<br />- 54. Cannabinoids |
| Session: |
103. Behavioral pharmacology I Slide |
| Presentation Time: | Sunday, November 5, 2000 2:30 PM-2:45 PM |
| Location: | Room 268 |
| Keywords: | IMAGING, CANNABINOIDS, BLOOD FLOW, ATTENTION |
We have previously reported PET rCBF data from 5 volunteers following smoking of a marijuana cigarette (SNS 1998). The present study measured rCBF with PET using [O-15]water in 12 new volunteers (6M, 6F) who were occasional recreational users of marijuana. Subjects were imaged prior to and following smoking of a marijuana (20 mg THC) and placebo (marijuana with THC removed) cigarette as they repeatedly performed an auditory attention task. A double-blind design was used with order of THC and placebo counterbalnced across subjects. Subtraction of the post-placebo from the post-THC condition revealed dramatic rCBF increases in orbital frontal cortex, anterior cingulate, temporal pole, insula, and lateral cerebellum. Smoking marijuana decreased rCBF in L heschl’s gyrus, primary visual cortex, and a number of frontal regions (BA4, 6, 8, 10). Ventral brain regions showing increased rCBF may mediate the intoxicating and mood-related effects of smoking marijuana. The rCBF decreases in primary sensory cortices and dorsal frontal lobe may relate to the acute cognitive impairment caused by the drug.
Supported by DA10551 & MHCRC43271
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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