Neuroscience 2005 Abstract
| Presentation Number: | 997.2 |
|---|---|
| Abstract Title: | Hippocampal CA1 pyramidal neuron activity during trace eyeblink conditioning with a whisker vibration conditioned stimulus. |
| Authors: |
Weible, A. P.*1
; Flores, L. C.1
; Disterhoft, J. F.1
1Dept Physiol, Northwestern Univ. Feinberg School of Medicine, Chicago, IL |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Associative, nonassociative, and skill learning |
| Session: |
997. Associative, Nonassociative, and Skill Learning: Other Brain Areas Poster |
| Presentation Time: | Wednesday, November 16, 2005 2:00 PM-3:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # LL19 |
| Keywords: | interneuron, vibrissae, associative learning |
Whisker stimulation is an effective conditioning stimulus (CS) for trace eyeblink conditioning (EBC) in rabbits. The whisker-CS is of interest for the study of learning and memory, given learning-specific metabolic changes observed in our laboratory in the somatotopic map of the whisker barrel field cortex (Galvez et al, SFN Abs 2005). In the present study, we sought to determine whether the hippocampus, critical for the acquisition of trace EBC, exhibits single neuron activity changes in vivo with a whisker-CS similar to those observed during tone-CS trace EBC. A total of 38.1% (82/215) of CA1 pyramidal neurons from 3 trace conditioned rabbits exhibited significant increases in activity (z>1.96) during CS (250ms), trace (500ms), US (150ms) and/or post-US (1000ms) intervals compared to baseline (1000ms). Stimulus-evoked responses developed as early as the first day of training (80 trials/session, mean trials to initial conditioned responses: 124±81, S.E.). The evidence for stimulus-evoked increases in firing rate as early as the first day of training was unexpected, and will be further examined with comparisons of single neuron data recorded during trace and pseudo conditioning. These neuronal responses were significantly greater during the CS (df=288, t=3.191, p=.0016), but not the US (p=.0855), interval, than those observed from 1 additional rabbit which failed to acquire the task, results which are similar to those reported in comparisons with tone-CS pseudo conditioned subjects. The mean response topography, and proportion responsive, of CA1 pyramidal neurons from the 3 trained rabbits were similar to those reported previously during tone-CS trace EBC. The data suggest that the hippocampus processes tone- and whisker-CS information in a similar fashion. We will also examine interneuron activity during trace and pseudo conditioning in order to better understand how patterns of activation observed during trace EBC in CA1 pyramidal neurons and interneurons correlate during learning. .
Supported by MH047340
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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