Neuroscience 2005 Abstract
| Presentation Number: | 985.17 |
|---|---|
| Abstract Title: | Tactile activation of putative area MT+ in the squirrel monkey revealed with 9.4 T fMRI. |
| Authors: |
Nelson, A. J.*1
; Cheney, C. A.1
; Chen, I.2
; Dai, G.2
; Grindlay, G.1
; Kempadoo, K.1
; Ramanathan, A.1
; Moore, C. I.1,2
1McGovern Inst. Brain Res., Massachusetts Inst. of Technology, Cambridge, MA 2MA, E25-414, 02139, |
| Primary Theme and Topics |
Sensory and Motor Systems - Tactile/Somatosensory -- Thalamus and Cortex |
| Secondary Theme and Topics | Sensory and Motor Systems<br />- Multisensory |
| Session: |
985. Tactile/Somatosensory: Thalamus and Cortex V Poster |
| Presentation Time: | Wednesday, November 16, 2005 1:00 PM-2:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # EE20 |
| Keywords: |
Area MT has been classically defined as a visual motion area that is also responsive to temporally varying spatially stable stimuli (flicker). We have recently demonstrated that vibrotactile stimuli, that do not evoke a motion percept, drive area MT+ in the human (Aparicio & Moore, SFN 2005; Moore et al., SFN 2005). Here, we investigated activity in MT+ with stable vibrotactile and tactile apparent motion (TAM) stimuli in lightly anesthetized squirrel monkeys. Vibrotactile stimulation was administered to the 2nd digit middle and proximal segments. In the simultaneous condition, vibration onset at both skin contacts occurred in synchrony and was maintained for 300 msec; in the TAM condition, 200 msec trains were presented asynchronously, with a 100 ms offset. This stimulation produces a motion percept in humans (Kirman, 1974; Aparicio & Moore, 2005 SFN). Stimuli were delivered using a blocked design (8 seconds on/12s off, 2 Hz presentation rate). EPI imaging was performed using single-shot symmetric spin-echo (TR = 2s, TE = 25.4ms) with an in-plane resolution of 625 microns and a slice thickness of 1 mm. Images were collected using a custom-made receive-transmit surface coil (6 cm x 5 cm oval). Isoflurane anesthesia (mean expired 0.62 %) was maintained in oxygen and physiological variables monitored (SpO2, heart rate, blood pressure, end-tidal CO2). Activation in the posterior bank of the superior temporal sulcus at its dorsal extent, the position of area MT in squirrel monkeys, was observed in all sessions (N = 5; 2 monkeys). Distinct foci were consistently observed in this region: A more ventral activation at the genu where the STS ascends vertically, and a posterior region at the STS dorsal termination. We are currently conducting visual fMRI at 9.4 T and anatomical studies to reveal the position of area MT relative to these activation zones.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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