Neuroscience 2005 Abstract
| Presentation Number: | 983.5 |
|---|---|
| Abstract Title: | The cortical activation pattern of delayed onset muscle soreness (DOMS). |
| Authors: |
Zimmermann, K.*1
; Carr, R. W.1
; Hullard-Pulstinger, C.1
; Kaschka, M.1
; Handwerker, H. O.1
; Forster, C.1
1Dept. of Physiology and Pathophysiology, Friedrich-Alexander Univ. of Erlangen-Nuremberg, Erlangen, Germany |
| Primary Theme and Topics |
Sensory and Motor Systems - Pain -- Pain imaging and perception |
| Secondary Theme and Topics | Cognition and Behavior<br />- Human Cognition, Behavior, and Anatomy<br />-- Perception and imagery |
| Session: |
983. Thalamic and Cortical Processing of Pain Poster |
| Presentation Time: | Wednesday, November 16, 2005 1:00 PM-2:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # DD15 |
| Keywords: | MUSCLE PAIN, FUNCTIONAL MRI, CINGULATE CORTEX, INSULA |
DOMS is a common physiological pain state following a bout of eccentric muscle contractions. We used magnetic resonance imaging (MRI) to study its cortical activation pattern. Eight healthy volunteers were subjected to a series of eccentric contractions in their right quadriceps muscle group. The left leg served as control. 48 hours later, subjects were psychophysically evaluated and found to experience intense soreness in the vastus lateralis, medialis and the iliotibial tract. The stimulus paradigm involved 5 cycles of alternate repeated voluntary contractions of the right sore and the left sound quadriceps muscle group (24 seconds each) with eleven interleaved resting conditions (18 seconds each). A light signal indicated the sequence of the protocol. A contrast analysis of the painful versus the non-painful stimulus disclosed the pain matrix as similar to that for cutaneous pain, however in addition with strong activations spanning large areas of the cingulate cortex from posterior anterior to posterior parts. Pain-related activations were also found in premotor (M2) and precuneal areas, the latter one recognized as a visuomotor coordinative area. Pain-related activations in the insular cortex were mainly left-sided and located in medial and posterior areas. Frontal activations beyond motor areas were scarce. Thalamus, basal ganglia and cerebellar activations were also noted. In the contrast analysis, non-painful contraction activated only primary sensory (S1) and precuneal areas. However, the onset of the non-painful contraction induced a very short increase in the BOLD signal in virtually all areas with activation during the painful task. We assume that the painful sensation and the aversion connected to a movement of a muscle after an eccentric contraction is reflected in an extended activation of the respective S1 and M2 areas and that the cingulate and insular cortices are part of those structures where the unpleasantness of this perception is encoded. Supported by DFG, SFB353 C1.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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