Neuroscience 2003 Abstract
| Presentation Number: | 949.11 |
|---|---|
| Abstract Title: | MRI safety test at 1.5-tesla of a deep brain stimulation lead and trajectory guide. |
| Authors: |
Krahl, S. E.*1
; Bronstein, J. M.2
; Sinha, S.3
; Ahn, S.3
; Frysinger, R. C.4
; Cohen, M. S.2,3
; Behnke, E. J.1
; Bhidayasiri, R.2
; DeSalles, A. A. F.1
; Shellock, F. G.
1Neurosurgery, Univ. of California, Los Angeles, CA 2Neurol., Univ. of California, Los Angeles, CA 3Radiation Oncology, Univ. of California, Los Angeles, CA 4NeuroBiol., Univ. of California, Los Angeles, CA |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Neurodegenerative Disorders -- Parkinson's Disease: Other |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Neurodegenerative Disorders<br />-- Parkinson's Disease: Experimental therapies |
| Session: |
949. Parkinson's Disease: Other III Poster |
| Presentation Time: | Wednesday, November 12, 2003 3:00 PM-4:00 PM |
| Location: | Morial Convention Center - Hall F-I, Board # Z6 |
| Keywords: | stereotactic neurosurgery, DBS, Parkinson's disease, essential tremor |
Stereotactic placement of deep brain stimulation (DBS) leads for the treatment of movement disorders has traditionally been guided by microrecording and macrostimulation in awake patients, with subsequent confirmation by MRI after the lead’s stylet has been removed. When placement errors occur, the surgery must be repeated and the lead replaced. Visual guidance by concurrent MRI would improve placement accuracy and reduce the need for repeated surgeries. An MRI-compatible trajectory guidance system (IGN) has been developed to fix DBS leads in place without removing the stylet, and allow remote adjustment of the lead position as needed. In preparation for clinical applications, we performed safety tests of this device in a 1.5-Tesla Siemens Sonata MR system.
We evaluated local temperature changes using clinically relevant and ¨worst-case¨ MRI sequences in a semi-solid, gel-filled phantom. The lead tip (Medtronic), with stylet in place, was immersed into the phantom using the trajectory guide and remote introducer. MRI sequences were performed using an RF-transmit body coil and receive-only head coil with calculated whole-body specific absorption rates (SARs) varying from 0.1 to 3.4 W/kg, and up to 3.1 W/kg in the head. Temperature increases at the lead tip, as measured with a fluoroptic thermometry system (Luxtron), did not exceed 1°C using any of the scanning sequences. This temperature increase is well within physiologically acceptable levels. These data offer no evidence of specific risk to patient safety from the use of the IGN guidance system during clinically relevant MRI procedures.
We evaluated local temperature changes using clinically relevant and ¨worst-case¨ MRI sequences in a semi-solid, gel-filled phantom. The lead tip (Medtronic), with stylet in place, was immersed into the phantom using the trajectory guide and remote introducer. MRI sequences were performed using an RF-transmit body coil and receive-only head coil with calculated whole-body specific absorption rates (SARs) varying from 0.1 to 3.4 W/kg, and up to 3.1 W/kg in the head. Temperature increases at the lead tip, as measured with a fluoroptic thermometry system (Luxtron), did not exceed 1°C using any of the scanning sequences. This temperature increase is well within physiologically acceptable levels. These data offer no evidence of specific risk to patient safety from the use of the IGN guidance system during clinically relevant MRI procedures.
Supported by VA, NIDA (DA15549), Parkinson's Disease Foundation, Medtronic, & IGN
<B>Conflict of Interest:</B> Several authors have received speaking honoraria and grant/equipment support from one or more of the study sponsors.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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