Neuroscience 2000 Abstract
| Presentation Number: | 96.16 |
|---|---|
| Abstract Title: | Tolerance, dependence and motivational responses to cannabinoids in μ, δ, or κ opioid receptor knockout mice. |
| Authors: |
Ghozland, S.*1
; Robledo, P.1
; Filliol, D.2
; Simonin, F.2
; Matthes, H.2
; Kieffer, B. L.2
; Maldonado, R.1
1Neuropharmacol., Univ. Pompeu Fabra, Barcelona, Spain 2ESBS, Illkirch, France |
| Primary Theme and Topics |
J. Disorders of the Nervous System and Aging - 146. Drugs of abuse: opioids and others |
| Secondary Theme and Topics | D. Neurotransmitters, Modulators, Transporters, and Receptors<br />- 54. Cannabinoids |
| Session: |
96. Drugs of abuse: morphine and THC Poster |
| Presentation Time: | Sunday, November 5, 2000 11:00 AM-12:00 PM |
| Location: | Hall G-J |
| Keywords: | THC, reward, abstinence, tolerance |
Cross-interactions between opioid and cannabinoid systems in dependence and reward-related processes have been shown in many studies. We have recently established in mice a model of tolerance and dependence to Δ9-tetrahydrocannabinol (THC) as well as a model of place conditioning to evaluate both rewarding and aversive properties of THC. These two models represent useful tools for the study of the neurobiological basis of THC actions. We have now used these models in three strains of knockout mice lacking either μ, δ or κ opioid receptors, to determine the implication of each opioid receptor in tolerance and dependence to THC as well as in the motivational effects induced by this compound. In each strain of knockout mice, we first studied the rewarding and aversive effects of THC (1 and 5 mg/kg) in the place conditioning paradigm. We then studied the development of tolerance to the antinociceptive, hypothermic, and hypolocomotor effects of THC during chronic treatment (20 mg/kg, twice daily). Finally, THC-dependent mice received an injection of the CB1 antagonist SR141716A (10 mg/kg), and the different somatic manifestations of withdrawal were evaluated. We report here interesting cross-interactions between the two systems that may help to understand the mechanisms of action of cannabinoids. These results can also clarify the involvement of the opioid system in the adaptive responses occuring during chronic THC exposure leading to the development of tolerance and dependence.
Supported by Dr. Esteve S.A. Lab., European Commission (BIOMED-2 #98-2227), FIS(99/0624)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
Copyright © 2000-2025 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
