Neuroscience 2004 Abstract
| Presentation Number: | 946.1 |
|---|---|
| Abstract Title: | White matter injury assessed by MRI in premature infants with intraventricular hemorrhage. |
| Authors: |
Drobyshevsky, A.*1
; Storey, P.2
; Meyer, J.2
; Prasad, P.2
; Tan, S.1
; MacKendrick, W.1
1Pediatrics, Evanston Hosp., Evanston, IL 2Radiology, Evanston Hosp., Evanston, IL |
| Primary Theme and Topics |
Development - Development of Motor Systems |
| Session: |
946. Mechanisms of Development II Poster |
| Presentation Time: | Wednesday, October 27, 2004 1:00 PM-2:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # E24 |
| Keywords: | MRI, NEONATAL |
Introduction
Intraventricular hemorrhage (IVH), a frequent complication in premature infants, is associated with parenchymal injury including white matter injury.
Hypothesis: We hypothesized that the processes that cause IVH in premature babies would also result in white matter injury. Our objective was to investigate the effect of IVH on white matter injury as assessed by diffusion tensor imaging (DTI).
Methods
Premature infants, born at less than 32 weeks gestational age, underwent DTI MRI scans at 10-14 days of life and again at 37 weeks postconceptional age. Using T1, T2 and FLAIR images, patients were assigned into 2 groups: normal controls (n=12) or IVH group (total n=7: 4 with Grade I-II and one PVL, 3 with III-IV). Diffusion coefficient (ADC), fractional anisotropy (FA) and directional correlation (DC) were measured on multiple regions of interest.
Results
There was a decrease in FA and increase in ADC with age for white matter tracts; the opposite changes occurred for gray matter. Comparing the two groups, we found that DC was significantly lower in the IVH group in the first study in the areas of the posterior limb of the internal capsule (PLIC), corpus callosum splenium (CC_S), frontal white matter and optic radiation (p<0.05, t-test). FA in these areas tended to be lower in the IVH group. On the second study, the values of DC and FA in the IVH group reached the values of the control group and in CC_S even exceeded them, with a greater increase in FA values between the two scans in PLIC in the IVH group (p<0.05, Repeated Measures ANOVA).
Discussion
The IVH group had evidence of white matter injury on the first scan. We speculate that the processes that cause IVH also result in white matter injury. The increased FA changes seen on the second scan in the IVH group may reflect the plasticity and repair mechanisms of premature babies and would suggest that the white matter developmental response to injury is complex.
Intraventricular hemorrhage (IVH), a frequent complication in premature infants, is associated with parenchymal injury including white matter injury.
Hypothesis: We hypothesized that the processes that cause IVH in premature babies would also result in white matter injury. Our objective was to investigate the effect of IVH on white matter injury as assessed by diffusion tensor imaging (DTI).
Methods
Premature infants, born at less than 32 weeks gestational age, underwent DTI MRI scans at 10-14 days of life and again at 37 weeks postconceptional age. Using T1, T2 and FLAIR images, patients were assigned into 2 groups: normal controls (n=12) or IVH group (total n=7: 4 with Grade I-II and one PVL, 3 with III-IV). Diffusion coefficient (ADC), fractional anisotropy (FA) and directional correlation (DC) were measured on multiple regions of interest.
Results
There was a decrease in FA and increase in ADC with age for white matter tracts; the opposite changes occurred for gray matter. Comparing the two groups, we found that DC was significantly lower in the IVH group in the first study in the areas of the posterior limb of the internal capsule (PLIC), corpus callosum splenium (CC_S), frontal white matter and optic radiation (p<0.05, t-test). FA in these areas tended to be lower in the IVH group. On the second study, the values of DC and FA in the IVH group reached the values of the control group and in CC_S even exceeded them, with a greater increase in FA values between the two scans in PLIC in the IVH group (p<0.05, Repeated Measures ANOVA).
Discussion
The IVH group had evidence of white matter injury on the first scan. We speculate that the processes that cause IVH also result in white matter injury. The increased FA changes seen on the second scan in the IVH group may reflect the plasticity and repair mechanisms of premature babies and would suggest that the white matter developmental response to injury is complex.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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