Neuroscience 2004 Abstract
| Presentation Number: | 936.13 |
|---|---|
| Abstract Title: | MRI-guided pathology in brain banking for multiple sclerosis. |
| Authors: |
Ravid, R. R.*1
1Netherlands Brain Bank, Amsterdam, The Netherlands |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Demyelinating Disorders |
| Session: |
936. Multiple Sclerosis IV Slide |
| Presentation Time: | Wednesday, October 27, 2004 4:00 PM-4:15 PM |
| Location: | San Diego Convention Center - Room 25A |
| Keywords: |
Rivka Ravid, W.Kamphorst, L. Boe, P.Van der Valk, C.Polman, F. Barkhof, J. Guerts, H. Vrenken, J. Bot
The Netherlands Brain Bank, Pathological Institue , MS Centrum , Amsterdam, The Netherlands.
Brain Banks for research on Multiple Sclerosis (MS) are an essential repository for post-mortem specimens obtained at autopsy.The rapidly growing number of sophisticated neurobiological techniques applied on post-mortem brain tissues increases the pressure on brain banks to supply suitable autopsy material to the scientific community. The golden standard protocol of modern models for brain banks should comprise the following 7 basic entities;
1.A well established local donor system in which consent is obtained for the use of tissues for scientific research.
2. Compatibility of protocols for tissue procurement, management, preparation and storage for diagnostics and scientific research.
3. Rapid autopsies with a very short post-mortem delay and a fresh dissection; these are a prerequisite for an increasing range of technical procedures and new systems such as neuronal cultures.
4.A generally accepted consensus on the clinical and neuropathological criteria.
5. Quality control of the dissemintaed samples.
6.Abide by the internationally accepted guidelines for the ethical and legal aspects.
7. Proper safety procedures.
The rapid progress of molecular genetics has enormously helped in the elucidation of some of the causes of several major neurological and psychiatric diseases . In the coming decenia brain banks worldwide will have to collect, preserve and type DNA and RNA from brain specimens obtained via autopsy systems.
These guidelines make brain banks go round and guarantee the suitability of collected samples which in turn has its spin-off in modern scientific research.
The Netherlands Brain Bank, Pathological Institue , MS Centrum , Amsterdam, The Netherlands.
Brain Banks for research on Multiple Sclerosis (MS) are an essential repository for post-mortem specimens obtained at autopsy.The rapidly growing number of sophisticated neurobiological techniques applied on post-mortem brain tissues increases the pressure on brain banks to supply suitable autopsy material to the scientific community. The golden standard protocol of modern models for brain banks should comprise the following 7 basic entities;
1.A well established local donor system in which consent is obtained for the use of tissues for scientific research.
2. Compatibility of protocols for tissue procurement, management, preparation and storage for diagnostics and scientific research.
3. Rapid autopsies with a very short post-mortem delay and a fresh dissection; these are a prerequisite for an increasing range of technical procedures and new systems such as neuronal cultures.
4.A generally accepted consensus on the clinical and neuropathological criteria.
5. Quality control of the dissemintaed samples.
6.Abide by the internationally accepted guidelines for the ethical and legal aspects.
7. Proper safety procedures.
The rapid progress of molecular genetics has enormously helped in the elucidation of some of the causes of several major neurological and psychiatric diseases . In the coming decenia brain banks worldwide will have to collect, preserve and type DNA and RNA from brain specimens obtained via autopsy systems.
These guidelines make brain banks go round and guarantee the suitability of collected samples which in turn has its spin-off in modern scientific research.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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