Neuroscience 2004 Abstract
| Presentation Number: | 919.3 |
|---|---|
| Abstract Title: | Cross modal sensory processing assessments in rodent models of early brain damage. |
| Authors: |
Chen, J.*1
; McClure, M. M.1
; Fitch, R. H.1
; Markus, E. J.1
1Dept. of Psychology, Univ Connecticut, Storrs, CT |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Developmental Disorders -- Acquired |
| Session: |
919. Developmental Disorders: Sensory and Metabolic Disorders Poster |
| Presentation Time: | Wednesday, October 27, 2004 10:00 AM-11:00 AM |
| Location: | San Diego Convention Center - Hall A-H, Board # EEE29 |
| Keywords: | hypoxia, ischemia, dyslexia, development |
Language disabilities associated with perinatal brain damage (e.g., premature/very low birthweight (VLBW) populations) may be related to fundamental deficits in processing of rapid auditory information. Accordingly, rapid auditory processing deficits are seen in language impaired, dyslexic, and premature/VLBW populations. This does not seem limited to the auditory modality since deficits in processing rapidly changing visual cues have also been seen in these populations. Overall the evidence suggests that disruptions of key neurodevelopmental events leads to pervasive cross-modal alterations in basic sensory processing, which in turn underlie some disruptions of language development.
We have studied rodent models of early brain damage using an array of auditory processing measures. Results consistently show that focal developmental malformations of cortex, and perinatal hypoxic-ischemic insults, are associated with disruptions of rapid auditory processing (e.g., Peiffer et al., SFN, 2003; McClure et al., SFN, 2003). More recently we have begun to examine the degree to which these effects are also evident in visual processing.
Adult male Wistar rats with a variety of induced early brain injuries were behaviorally evaluated on both auditory and visual versions of a modified startle reduction paradigm. Some discrimination tasks carried little temporal demand (e.g., single tone detection, visual grating acuity), while others contained significant temporal demand (e.g., brief two-tone sequence discrimination, brief checker-board reversal discrimination). Questions examined:
1) what aspects of processing are affected by the brain injury; 2) whether cross-correlations in individual performance are seen across modalities; and 3) if so, whether these cross-modal indices provide a more reliable and robust assessment of processing deficits in impaired subjects.
We have studied rodent models of early brain damage using an array of auditory processing measures. Results consistently show that focal developmental malformations of cortex, and perinatal hypoxic-ischemic insults, are associated with disruptions of rapid auditory processing (e.g., Peiffer et al., SFN, 2003; McClure et al., SFN, 2003). More recently we have begun to examine the degree to which these effects are also evident in visual processing.
Adult male Wistar rats with a variety of induced early brain injuries were behaviorally evaluated on both auditory and visual versions of a modified startle reduction paradigm. Some discrimination tasks carried little temporal demand (e.g., single tone detection, visual grating acuity), while others contained significant temporal demand (e.g., brief two-tone sequence discrimination, brief checker-board reversal discrimination). Questions examined:
1) what aspects of processing are affected by the brain injury; 2) whether cross-correlations in individual performance are seen across modalities; and 3) if so, whether these cross-modal indices provide a more reliable and robust assessment of processing deficits in impaired subjects.
Supported by UConn FRS444880; 445142; NIH #R29-A613941-01A1
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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