Neuroscience 2005 Abstract
| Presentation Number: | 923.17 |
|---|---|
| Abstract Title: | The effects of cocaine and methylphenidate on the human brain: a group-level independent component analysis of pharmacological MRI data. |
| Authors: |
Chen, S.*1,2
; Yang, Y.1
; Ross, T. J.1
; Chuang, K. S.2
; Stein, E. A.1
1National Inst. on Drug Abuse, Baltimore, MD 2Taiwan, 5500 Nathan Shock Dr, 21224, |
| Primary Theme and Topics |
Techniques in Neuroscience - Data Analysis and Statistics |
| Secondary Theme and Topics | Disorders of the Nervous System<br />- Addiction and Drugs of Abuse<br />-- Cocaine |
| Session: |
923. Techniques in Neuroscience II Poster |
| Presentation Time: | Wednesday, November 16, 2005 8:00 AM-9:00 AM |
| Location: | Washington Convention Center - Hall A-C, Board # WW27 |
| Keywords: |
Introduction: Most previous pharmacological MRI (phMRI) studies have used hypothesis-driven approaches for data analysis. However, the temporal pattern of brain response to a drug injection is not precisely known and head motion associated with drug administration can confound the results. Independent component analysis (ICA) is a data-driven method that does not require a priori knowledge about signal response patterns. In this study, we used group ICA to analyze phMRI BOLD data following cocaine and methylphenidate (MP) administration. Methods: Nine cocaine users received 3 IV drug injections (20mg/70kg cocaine, 10 and 20mg/70kg MP injected over 30sec). During each of 3 scan sessions, subjects received one IV injection of drug and 1 of saline. Whole brain BOLD images were acquired from 4 minutes before to 34 minutes after injection using a modified EPI sequence. A fast ICA algorithm was utilized to analyze the temporally concatenated functional data. An image voxel in an ICA component map was considered as “activated” if its intensity significantly deviated from the mean intensity of the component map (z>2.5; p<0.02). Time courses corresponding to constituent components were reconstructed. Results and Discussion: Activated areas were observed in the orbital frontal cortex, anterior and posterior cingulate cortex, medial frontal gyrus, caudate, insula and thalamus following bulk cocaine and MP administration. These results generally correspond to those obtained from pharmacological-model based analysis, although more activated brain areas were detected using ICA. Head motion was observed in a few components, characterized as enhanced signal in the boundary of the brain. Other components related to behavior ratings and blood pressure measurements during the experiment were also identified. The separation of non-direct from direct drug effects may help improve sensitivity and accuracy of phMRI.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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