Neuroscience 2003 Abstract
| Presentation Number: | 910.3 |
|---|---|
| Abstract Title: | Precision of response timing in primary visual cortex: evidence for a high conductance state? |
| Authors: |
Henrie, J. A.*1
; Tao, L.2
; Shelley, M.2
; Shapley, R.1
1Ctr. for Neural Sci., New York Univ, New York, NY 2Courant Inst. of Mathematical Sci., New York Univ, New York, NY |
| Primary Theme and Topics |
Sensory Systems - Vision -- Visual cortex: Neural coding |
| Session: |
910. Striate Cortex: Neuronal Properties Poster |
| Presentation Time: | Wednesday, November 12, 2003 3:00 PM-4:00 PM |
| Location: | Morial Convention Center - Hall F-I, Board # E62 |
| Keywords: | MODEL, SINGLE UNITS, NEURAL CODING, NETWORK |
Recording of single unit responses in macaque primary visual cortex (V1) to repeated stimulation of identical stimulus sequences show a precision of spike times on the order of a few ms. These experimental findings are compared with a large-scale neuronal network model, based upon V1 anatomy and physiology, which has successfully accounted for a variety of functional tuning properties of V1 (Tao et al. 2003 SFN Abst. Vol 27, 2001). We define precision as the standard deviation of first spike times during a well isolated event according to the methods proposed by Bair & Koch (Neural Comput. 8:1185-1202, 1996). Events are defined as periods when the instantaneous firing rate, estimated across many repeats(>60), goes above a threshold. In order to evoke such events, stimuli rich in temporal transients were used. Typically these were taken from an ensemble of stationary sinusoidal gratings spanning many orientations, spatial phases, and frequencies. A particular stimulus sequence consists of a series of randomly chosen gratings flashed for 40 ms each. Here we report that most neurons show instances of repeatable firing times to within 1-2 ms when stimulated with such naturalistic stimulus sequences. The neurons of the large-scale network model under the same experimental protocol show comparable responses. Most of the individual units in the network displayed an abundance of well-isolated events which contained spikes precise on the order of single ms. The hallmark property of this network is that under stimulation the individual neurons are in a state of high intracellular conductance, during which the effective membrane timescale shrinks to a few ms (Shelley et al. J. Comput. Neurosci., 13(2):93-109, 2002). We interpret the high precision of spike times in both the network model and in V1 as evidence for such a high conductance state in vivo.
Supported by RO1EY01472, T32EY7158, and the Swartz Foundation.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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