Neuroscience 2004 Abstract
| Presentation Number: | 919.1 |
|---|---|
| Abstract Title: | Deficits in auditory processing in rats in relation to severity of neonatal hypoxic-ischemic damage. |
| Authors: |
McClure, M. M.*1
; Threlkeld, S. W.1
; Rosen, G. D.2
; Fitch, R.1
1Dept Psych, Univ Conn, Storrs, CT 2MA, 3107 Horsebarn Hill Dr, 06268, |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Developmental Disorders -- Acquired |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Ischemia<br />-- Global Ischemia |
| Session: |
919. Developmental Disorders: Sensory and Metabolic Disorders Poster |
| Presentation Time: | Wednesday, October 27, 2004 8:00 AM-9:00 AM |
| Location: | San Diego Convention Center - Hall A-H, Board # EEE29 |
| Keywords: | prematurity, very low birthweight, language impairment, developmental disorders |
Hypoxia-ischemia (HI) refers to reduced blood oxygenation and/or diminished amount of blood perfusing the brain, and represents a common cause of injury to the premature/very low birthweight (VLBW) infant brain. Significant number of premature/VLBW infants go on to experience cognitive/behavioral deficits, including language impairments. Parallel research has demonstrated that auditory processing deficits may play a causal role in the development of language impairments, and auditory processing deficits have been observed in premature/VLBW populations. Based on convergent evidence, we performed behavioral evaluations of a rat model of perinatal HI injury, and have reported deficits on rapid auditory tasks and spatial learning/memory tasks for male rats with early unilateral HI injury (McClure et al., SFN, 2003). In the current study, we explore the behavioral consequences of a bilateral HI injury in male rats. Results show that bilateral HI subjects performed worse than shams and unilateral HI subjects on tasks requiring rapid auditory processing, although these effects were not seen on simpler versions of the tasks. Cumulative findings suggest that perinatal HI injury in the rat may lead to neurodevelopmental damage associated with rapid auditory processing deficits, and that more severe damage appears to be associated with more profound deficits. These findings have critical implications for the study of the etiology underlying cognitive and language deficits in premature/VLBW children.
Supported by UConn Research Foundation
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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