Neuroscience 2001 Abstract
| Presentation Number: | 970.3 |
|---|---|
| Abstract Title: | Adenosine Receptor Agonists Produce Enduring Increases in Cerebral Blood Flow in Rat Brain: Assessment by Spin-labeled Magnetic Resonance Imaging. |
| Authors: |
Kochanek, P. M.*1
; Hendrich, K. S.2
; Jackson, E. K.3
; Melick, J. A.1
; Williams, D. S.2
; Wisniewski, S. R.4
; Ho, C.2
1Anesthesiology/CCM, Safar Center for Resuscitation Research, Pittsburgh, PA 2Pittsburgh NMR Center, Carnegie Mellon University, Pittsburgh, PA 3Dept. of Clinical Pharmacology, University of Pittsburgh, Pittsburgh, PA 4Dept. of Epidemiology, University of Pittsburgh, Pittsburgh, PA |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Cerebral Blood Flow |
| Session: |
970. Cerebral blood flow III Poster |
| Presentation Time: | Thursday, November 15, 2001 10:00 AM-11:00 AM |
| Location: | Exhibit Hall WW-55 |
| Keywords: | NMR, PURINERGIC, CORTEX, HIPPOCAMPUS |
Administration of adenosine receptor agonists increases cerebral blood flow (CBF,Van Wylen et al, 1989). We previously used arterial spin labeled magnetic resonance imaging (MRI) to map changes in CBF early after injection of the non-selective adenosine receptor agonist 2-chloroadenosine (2-CA) into rat brain (Kochanek et al, 2001). 2-4-fold increases in local and hemispheric CBF were seen. We now report the duration and receptor specificity of these effects. Anesthetized male Sprague-Dawley rats were injected with either saline vehicle (2 μl) or 2-CA (12 nmoles in 2 μl) into left dorsal hippocampus. At the NMR center, rats were anesthetized with pentobarbital and imaged at either ~3.5h or 1 day. MRI (perfusion, T1obs) was performed at 4.7T. CBF (ml/100g/min) in ipsilateral hippocampus was 217±50 (mean±SD) at ~3.5h after 2-CA injection vs 296±36 and 65±21 at ~24h in 2-CA and sham, respectively (p<0.05 for 2-CA vs sham at either time point). In cortex, CBF was 136±50 at ~3.5h after 2-CA injection vs 261±71 and 62±17 at ~24h in 2-CA and sham, respectively (p<0.05 for 2-CA vs sham at either time point and for 2-CA ~3.5h vs 2-CA 1 day). Injection of the selective A2a-receptor agonist CGS21680 also similarly increased CBF. 2-CA produces enduring increases in CBF after injection. A2a-receptor activation contributes to this response.
Supported by NS38087,RR-10962,RR03631
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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