Neuroscience 2001 Abstract
| Presentation Number: | 961.5 |
|---|---|
| Abstract Title: | Prenatal Morphogenesis: A Fetus Brain 3D MRI Study. |
| Authors: |
Cachia, A.*1
; Boddaert, N.1,5
; Mangin, J. F.1
; Regis, J.3
; Sonigo, P.5
; Bloch, I.4
; Zilbovicius, M.1,2
; Brunelle, F.5
1Service Hospitalier Frederic Joliot, CEA, Orsay, France 2U316, INSERM, Tours, France 3Hopital La Timone, Marseille, France 4TSI, ENST, CNRS URA 820, Paris, France 5Hopital Necker Enfants Malades, Paris, France |
| Primary Theme and Topics |
Cognition and Behavior - Development of Behavior |
| Secondary Theme and Topics | Cognition and Behavior<br />- Human Cognition and Behavior<br />-- Other higher functions |
| Session: |
961. Development of behavior: human studies Poster |
| Presentation Time: | Thursday, November 15, 2001 8:00 AM-9:00 AM |
| Location: | Exhibit Hall UU-37 |
| Keywords: | Brain imaging, brain developement, neurogenesis, maturation |
Brain fetal anatomy has been previously studied using echography , 2D MRI and post-mortem pathological examination. Fetus brain 3D MRI can offer a new perspective to study in vivo early stages of cerebral morphogenesis. Therefore, we performed MRI studies in five fetuses aged from 27 to 40 gestational weeks. The MRI was requested for medical reasons. MRI acquisition was performed on a 1.5 Tesla GE with the parameters: Fast Spin Echo T2, TR = 8000, TE = 120, voxel size: 1.4 x 1.4 x 4 mm. Acquisition time was about 2 minutes. No morphological pathology was detected. A semi-automatic cortical mantle detection was applied using a spherical deformable model whose deformations are driven by the contrast between CSF and gray matter. This procedure allows an anatomical 3D coherent reconstruction. An automatic curvature-based recognition of each sulcal roots was performed in each fetus brain and yielded a clear understanding of the dimples that mark the first stages of sulcal folding. The obtained 3D primal sketches of the main sulci appeared clearly on these images but on classical 2D images of the fetal brain. They were in accordance with anatomopathological atlases describing the development of the human fetal brain. The numbers of sulcal roots observed for the central sulcus match well with the first sulcal root maps previously built from embryological literature and patterns of buried gyri or interrupted sulci on adult brains.
Supported by France Foundation.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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