Neuroscience 2005 Abstract
| Presentation Number: | 72.2 |
|---|---|
| Abstract Title: | Arc/Arg3.1 mRNA expression in the neocortex induced by recent and remote spatial memory recall. |
| Authors: |
Gusev, P. A.*1
; Gubin, A. N.2
1Blanchette Rockefeller Neurosci Inst., Rockville, MD 2MD, 9601 Medical Ctr Drive, 20850, |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Learning and memory: Physiology and imaging |
| Secondary Theme and Topics | Cognition and Behavior<br />- Animal Cognition and Behavior<br />-- Cognitive learning and memory systems |
| Session: |
72. Place Cells I Poster |
| Presentation Time: | Saturday, November 12, 2005 2:00 PM-3:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # GG10 |
| Keywords: |
Understanding mechanisms of memory retrieval and its deficits, and detection of memory underlying neuronal plasticity is greatly impeded by a lack of precise knowledge of memory underlying brain circuits. We addressed these questions by mapping Arc/Arg 3.1 mRNA expression at the multiple rostro-caudal levels of the brain following platform search in the water-maze spatial task at 24 hr and 1 mo in memory retention as compared to swimming and naïve controls. We have recently found dissociation in activity of entorhinal cortex, CA3 and CA1 over a period of memory consolidation: while the entorhinal cortex and CA3 demonstrated a robust learning-specific signal during both recent and long-term memory recalls, CA1 specific activity was almost entirely limited to recent memory retrieval (Gusev, Alkon and Gubin, SFN, 2004). Following recent memory tests, we so far observed a learning-specific signal in the parietal, visual (I, IIL, IIM), motor, sensorimotor (I) and retrosplenial but not sensorimotor (II) cortices. In remote memory tests, we observed a learning-specific signal of a smaller magnitude only in the caudal retrosplenial, visual (I, IIL) but not in the parietal, motor, sensorimotor (I, II) and visual (IIM) cortices. The superficial cortical layers II-IV of both parietal and all visual cortices displayed stronger learning-specific signal as compared to layer VI during recent memory recall. During the remote memory recall, the difference between learning-specific signal in the superficial and deep layers was no longer present. In contrast to the hippocampus and neocortex, the thalamic reticular nucleus had an elevated basal Arc mRNA expression and displayed a modest but persistent learning-specific signal following performances on both recent and remote memory tasks. Our mapping data with a neuron-specific activity marker are in agreement with theoretical predictions of time-dependent reorganization of memory underlying neocortical and hippocampal circuitries.
Supported by BRNI
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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