Neuroscience 2003 Abstract
| Presentation Number: | 856.13 |
|---|---|
| Abstract Title: | Cocaine-induced neostriatal dopamine depletion in MDMA-pretreated rats. |
| Authors: |
Pierce, C.*1
; Yamamoto, B. K.1
1Dept. Pharmacol., Boston Univ. Sch. Med, Boston, MA |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Addiction and Drugs of Abuse -- Cocaine |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Addiction and Drugs of Abuse<br />-- Amphetamines |
| Session: |
856. Addiction and Drugs of Abuse: Cocaine VIII Poster |
| Presentation Time: | Wednesday, November 12, 2003 8:00 AM-9:00 AM |
| Location: | Morial Convention Center - Hall F-I, Board # TT27 |
| Keywords: | neurotoxicity, GBR-12909, neostriatum, dopamine |
MDMA addicts are frequently polydrug abusers, combining MDMA with alcohol and marijuana as well as other psychostimulants including cocaine. Although psychostimulants are similar pharmacologically, they differ substantially in terms of neurotoxic effects. Thus, whereas methylated amphetamines, such as MDMA, deplete neostriatal serotonin (5-HT), repeated administration of high doses of cocaine produces no toxic effects on central monoamine systems. In the present experiments, we administered a 5-HT toxic regimen of four repeated MDMA injections (10 mg/kg, i.p.) followed by seven daily injections of cocaine (15 mg/kg, i.p.) or the selective dopamine re-uptake blocker GBR-12909 (10 mg/kg, i.p.). Treatment with MDMA alone depleted neostriatal 5-HT while having no effect on neostriatal dopamine. The groups of rats pretreated MDMA and then administered cocaine or GBR-12909 had profound depletions of neostriatal 5-HT and dopamine. Taken together, these results indicate that blockade of dopamine reuptake is the main mechanism responsible for cocaine-induced neostriatal dopamine depletion in MDMA-pretreated rats. Based on these results, we hypothesize that the serial administration of MDMA and cocaine produces supersensitized dopamine transmission in the neostriatum that, via oxidative stress, results in dopamine as well as 5-HT depletions in the neostriatum.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
Copyright © 2003-2025 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
