Neuroscience 2001 Abstract
| Presentation Number: | 935.17 |
|---|---|
| Abstract Title: | Mapping of motor sensory activity in the human spinal cord with Functional MRI. |
| Authors: |
Morales, D.*1
; Favila, R.1
; Rojas, R.2
; Reynoso, G.2
; Barrios, F. A.1
1Centro de Neurobiologia, UNAM, Campus Juriquilla UNAM, Queretaro Qro., Mexico 2ABC Hospital, Mexico D. F. , Mexico |
| Primary Theme and Topics |
Motor Systems - Spinal Cord |
| Secondary Theme and Topics | Sensory Systems<br />- Tactile/Somatosensory<br />-- Pathways and processing |
| Session: |
935. Spinal cord: functional recovery Poster |
| Presentation Time: | Thursday, November 15, 2001 8:00 AM-9:00 AM |
| Location: | Exhibit Hall Z-7 |
| Keywords: | spinal cord, fMRI, sensorimotor, bold |
Functional magnetic resonance imaging (fMRI) of motor activation in the human cervical spinal cord has been attained by detecting blood oxygenization level dependent (BOLD) signal, by T2* weighted fast low angle shot (FLASH) imaging at 1.5 T (1), and similar results at 3.0 T (2). These studies showed ipsilateral response in the spinal cord during hand motion, and are important in order to determine the plausibility of functional mapping in structures of the central nervous system which are difficult to resolve. The objective of this work is to compare previously published results using FLASH-BOLD (1), with our studies using echo planar imaging (EPI) BOLD in the human spinal cord. Functional images from control volunteers were taken during sensorimotor on-off tasks, using a 1.5 T GE Signa LX scanner and T2* weighted EPI-BOLD pulse sequence, in five contiguous axial slices (8mm thick), centered at the cervical region at C6. Functional images were analyzed pixel by pixel with cross-correlation to a box car on-off paradigm. The functional maps were projected on co-registered high resolution T1 images to visualize the activated areas. These results show that functional images based on EPI-BOLD are very flow sensitive, generating high levels of noise, related to what we believe are flow effects from the CSF, diminishing the functional resolution of EPI imaging in fMRI spine studies.
(1) T. Yoshizawa, T. Nose, G.J. Moore and L.O. Sillerud, Neuroimage 4:174-182 (1996).
(2) P.W. Stroman, P.W. Nance and L.N. Ryner, Magn. Reson. Med. 42:571-576 (1999).
(1) T. Yoshizawa, T. Nose, G.J. Moore and L.O. Sillerud, Neuroimage 4:174-182 (1996).
(2) P.W. Stroman, P.W. Nance and L.N. Ryner, Magn. Reson. Med. 42:571-576 (1999).
Supported by CONACYT R31162-A
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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