Neuroscience 2001 Abstract
| Presentation Number: | 932.5 |
|---|---|
| Abstract Title: | Effects of rTMS as measured by diffussion-weighted MRI. |
| Authors: |
Gangitano, M.*1
; Mottaghy, F. M.1
; Pascual-Leone, A.1
; Schlaug, G.1
1Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA |
| Primary Theme and Topics |
Motor Systems - Cortex and Thalamus -- Imaging |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Cerebral Blood Flow |
| Session: |
932. Cortex and thalamus: imaging methods Poster |
| Presentation Time: | Thursday, November 15, 2001 8:00 AM-9:00 AM |
| Location: | Exhibit Hall V-5 |
| Keywords: | MRI, Motor Cortex, DIFFUSION |
It has been argued that the longer lasting effects of low-frequency rTMS trains rely on post-synaptic inhibitory GABAergic synapses, but there remains some uncertainty whether an additional pathophysiological mechanism might support this post-synaptic inhibition. In this study, we investigated whether rTMS at 1 Hz administered for 12 minutes at 90% of motor threshold to the primary motor cortex would lead to any changes in cortical diffusivity of water protons by comparing a series of diffusion weighted MRI (DWI) scans acquired before and after the rTMS train. Impairments of water diffusivity can typically be seen in the acute stage of an ischemic insult or focal status epilepticus, and their reversibility has been shown. Preliminary analysis of the diffusion images shows only a minimally increased signal within the motor region in half of the subjects (3 out of 6). This minimal signal change was no longer present 15 minutes after the end of the rTMS train. The initial signal change in some subjects is not comparable in magnitude to what is seen in acute ischemia or focal status and would be consistent with the notion that rTMS does not cause a cytotoxic edema.
Supported by NEI, NIMH, DFG(MO-871/3-1), IMFR, Fireman and Rubenstein Foundation
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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