Neuroscience 2001 Abstract
| Presentation Number: | 932.1 |
|---|---|
| Abstract Title: | REPRODUCIBILITY OF FUNCTIONAL MRI RESULTS. |
| Authors: |
Zhang, L. D.*1,2
; Yue, G. H.2
; Liu, J. Z.2
1Biomed Engineering, Case Western Reserve University, Cleveland, OH 2Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH |
| Primary Theme and Topics |
Motor Systems - Cortex and Thalamus -- Imaging |
| Session: |
932. Cortex and thalamus: imaging methods Poster |
| Presentation Time: | Thursday, November 15, 2001 8:00 AM-9:00 AM |
| Location: | Exhibit Hall V-5 |
| Keywords: | FUNCTIONAL MRI, BRAIN IMAGING, NOISE, MOTOR CONTROL |
Functional MRI (fMRI) is increasingly used in neuroscience research and clinical investigations. However, current knowledge regarding reproducibility of fMRI data is poor. The few studies dealing with this issue were based on experiments that were not performed under strictly controlled conditions. The purpose of this project was to examine reproducibility of fMRI results of a motor function study with precisely measured mechanical and electrical outputs of the muscles. Subjects performed handgrip contractions using a custom-built handgrip device and matched pre-set target force levels with assistance of a visual feedback system (Liu et al., J. Neurosci. Methods 101: 49-57, 2000). Each subject repeated three trials of a force-matching task (50% maximal force) in one session and the same session was repeated three times on three different days. Force and EMG signals of finger flexor and extensor muscles were recorded online with the fMRI data. Reproducibility of fMRI, force, and EMG results was determined by analyzing intra- and inter-session data variations. Based on the results of five subjects, intra-session and inter-session force and EMG variations were very low, indicating that the muscle outputs among sessions were almost identical. The fMRI data that represent brain signals controlling the muscle output were consistent among trials and sessions. These results suggest that despite the contributions of multiple (physiological and non-physiological) noise sources to fMRI signals, obtaining highly reproducible fMRI results is still possible, provided that experimental conditions are highly controlled and repeatable.
Supported by NIH grants NS35130, NS37400, and HD36725
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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