Neuroscience 2003 Abstract
| Presentation Number: | 847.13 |
|---|---|
| Abstract Title: | Direct measures of adiposity predict isotope-derived hepatic and adipocyte insulin sensitivity in schizophrenia. |
| Authors: |
Newcomer, J. W.*1
; Haupt, D. W.1
; Melson, A. K.1
; Schweiger, J. A.1
; Luber, A.1
; Maeda, J.1
; Hessler, M. J.1
; Flavin, K.1
1Psychiatry, Washington Univ. Sch. of Med., St Louis, MO |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Psychiatric Disorders -- Schizophrenia |
| Session: |
847. Schizophrenia: Antipsychotic Actions Poster |
| Presentation Time: | Wednesday, November 12, 2003 8:00 AM-9:00 AM |
| Location: | Morial Convention Center - Hall F-I, Board # HH10 |
| Keywords: | diabetes, glucose , lipid , metabolism |
Increased adiposity can disturb glucose and lipid metabolism via disturbances in insulin sensitivity, and schizophrenia patients experience an increased prevalence of diabetes mellitus in comparison to the general population. Increased adiposity, plasma glucose and lipids are independent risk factors for cardiovascular disease, and schizophrenia patients experience increased cardiovascular (CV) mortality in comparison to the general population. Adiposity can be directly measured using whole body dual energy x-ray absorptiometry (DEXA) and abdominal magnetic resonance imaging (MRI). These adiposity measures can be analyzed in relation to whole-body glucose and lipid kinetics measured with stable isotope tracer methodology during hyperinsulinemic-euglycemic clamp conditions. Subjects included patients with schizophrenia chronically treated with antipsychotic medications, and healthy untreated controls. Patients are part of a larger study involving subsequent prospective randomized assignment to different antipsychotic medications. Preliminary analyses indicate that direct measures of adiposity, including DEXA-based total body fat and MRI-based subcutaneous and visceral abdominal fat, predict various measures of glucose and lipid metabolism, including isotope-derived rate of appearance of glycerol (i.e., release of free fatty acids from adipocytes), rate of appearance of endogenous glucose (i.e., hepatic glucose production) and overall rate of disposal of glucose (i.e., predominantly transport into muscle). Sensitive techniques such as these can be used to carefully assess factors such as medication effects that may contribute to disturbances in glucose and lipid metabolism and cardiovascular risk in schizophrenia.
Supported by MH01510, MH63985, USPHS 5MO1 RR00036, P30 DK56341 and P60-DK20579
<B>Conflict of Interest:</B> Grants, Consultations & Research Disclosure Information Janssen Pharmaceutica Consultant Grant Support Speakers Bureau Eli Lilly and Company Consultant Grant Support Pfizer, Inc. Consultant Grant Support Speakers Bureau Astra
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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