Neuroscience 2002 Abstract
| Presentation Number: | 88.17 |
|---|---|
| Abstract Title: | Differences of Frontal Lobe Function between Adolescents with Disruptive Behavior Disorder and Normal Subjects as Assessed by Functional MRI. |
| Authors: |
Wang, Y.*1
; Mathews, V. P.1
; Lurito, J. T.1
; Lowe, M. J.1
; Dzemidzic, M.1
; Phillips, M. D.1
; Kronenberger, W. G.2
; Dunn, D.2
1Radiology, Indiana University School of Medicine, Indianapolis, IN 2Psychiatry, Indiana University School of Medicine, Indianapolis, IN |
| Primary Theme and Topics |
Cognition and Behavior - Aggression |
| Session: |
88. Aggression I Poster |
| Presentation Time: | Sunday, November 3, 2002 8:00 AM-9:00 AM |
| Location: | Hall A2-B3 V-23 |
| Keywords: | functional MRI, Disruptive Behavior Disorder |
Purpose: FMRI studies were performed using a Go-No-Go task (GNG) and a Counting Interference task (CI) to determine whether aggressive Disruptive Behavior Disorder (DBD) subjects show lower frontal lobe fMRI activation as compared to controls.
Methods: 15 DBD and 16 normal subjects were recruited. All subjects and their parents rated the subjects’ violent media exposure (VME). The DBD group had a significantly higher VME than the control group. Using 3D EPI sequence fMRI data were acquired while subjects performing the tasks. The GNG task required the subject to press a button for any presented letter, except X. The CI task required the subjects to press a button corresponding to the number of Xs for control periods and of identical numerals for activation periods, in which the numeral did not agree with the number of stimuli.
Results: There was no difference of behavior performance between DBD subjects and normal subjects. For GNG task, fMRI group map showed activation in the right DLPFC significantly greater in the control group than in the DBD group. For CI task, activation in the left DLPFC was observed significantly greater in the control group than in the DBD group. Analysis of variance indicated significant main effects for group and VME and a significant interaction effect between group and VME on the t-score of activated voxels of fMRI maps.
Conclusion: fMRI can identify differences in brain functioning between adolescents with and without aggressive DBD.
Methods: 15 DBD and 16 normal subjects were recruited. All subjects and their parents rated the subjects’ violent media exposure (VME). The DBD group had a significantly higher VME than the control group. Using 3D EPI sequence fMRI data were acquired while subjects performing the tasks. The GNG task required the subject to press a button for any presented letter, except X. The CI task required the subjects to press a button corresponding to the number of Xs for control periods and of identical numerals for activation periods, in which the numeral did not agree with the number of stimuli.
Results: There was no difference of behavior performance between DBD subjects and normal subjects. For GNG task, fMRI group map showed activation in the right DLPFC significantly greater in the control group than in the DBD group. For CI task, activation in the left DLPFC was observed significantly greater in the control group than in the DBD group. Analysis of variance indicated significant main effects for group and VME and a significant interaction effect between group and VME on the t-score of activated voxels of fMRI maps.
Conclusion: fMRI can identify differences in brain functioning between adolescents with and without aggressive DBD.
Supported by Center for successful parenting
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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