Neuroscience 2003 Abstract
| Presentation Number: | 823.6 |
|---|---|
| Abstract Title: | Assessing recovery from stroke using functional MRI: a serial case study. |
| Authors: |
Nair, D. G.*1
; Fuchs, A.1
; Steinberg, F. L.1,2
; Kelso, J. A. S.1
; Large, E. W.1
1Ctr. Complex Syst. & Brain Sci, Florida Atlantic Univ, Boca Raton, FL 2FL, 777 Glades Rd, 33431, |
| Primary Theme and Topics |
Motor Systems - Cortex and Thalamus -- Imaging |
| Session: |
823. Cortex and Thalamus: Functional Imaging Poster |
| Presentation Time: | Wednesday, November 12, 2003 9:00 AM-10:00 AM |
| Location: | Morial Convention Center - Hall F-I, Board # H67 |
| Keywords: | BRAIN IMAGING, FMRI, STROKE, MOTOR |
We used functional Magnetic Resonance Imaging (fMRI) to assess motor recovery in a patient with left middle cerebral artery (MCA) stroke. The patient was scanned on three occasions, at one-month intervals using a finger-sequencing paradigm consisting of both overt movement and movement imagery. Each of these finger-to-thumb opposition tasks were carried out in a prescribed sequence and consisted of three conditions, two unimanual and one bimanual. Although the first session showed more ipsilateral sensorimotor cortex activation during movement using the affected hand, later sessions exhibited more contralateral activation, which conforms to the pattern of the vascular response in normal subjects. However, blood flow to ipsilateral parietal cortex increased over sessions, suggesting that the undamaged parietal cortex took over the function of the affected side, even after improved blood flow to the contralateral sensorimotor cortex. Stronger activation was observed in the motor cortex of the lesion side and also in the peri-infarct area during bimanual execution and imagery compared to the unimanual tasks. We conclude that functional recovery from MCA stroke occurs through compensatory mechanisms involving at least bilateral sensorimotor cortices, contralateral cerebellum and ipsilateral parietal lobe. More activation observed in the rim of the infarct in the later sessions, suggests recovery. Use of both hands and motor imagery seems to enhance functional recovery from stroke and could have potential applications in rehabilitation of stroke patients.
Supported by NSF grant BCS-0094229 to EWL
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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