Neuroscience 2005 Abstract
| Presentation Number: | 67.7 |
|---|---|
| Abstract Title: | The roles of perirhinal glutamate receptor subtypes in the familiarity discrimination component of recognition memory. |
| Authors: |
Brown, M. W.*1
; Barker, G. R. I.1
; Warburton, E. C.1
1MRC Centre for Synaptic Plasticity, Department of Anatomy, Univ. of Bristol, Bristol, United Kingdom |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Cognitive learning and memory systems |
| Secondary Theme and Topics | Cognition and Behavior<br />- Animal Cognition and Behavior<br />-- Learning and memory: Pharmacology |
| Session: |
67. Cognitive Learning and Memory Systems: Recognition Memory Poster |
| Presentation Time: | Saturday, November 12, 2005 3:00 PM-4:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # DD15 |
| Keywords: | AMINO ACID, AMNESIA, TEMPORAL LOBE, NMDA |
Glutamate is the main cortical excitatory neurotransmitter. The familiarity discrimination component of recognition memory for individual objects is dependent on the integrity of the perirhinal cortex (see for review, Brown and Aggleton 2001 Nature Rev. Neurosci. 2: 51-61). The reported experiments were designed to investigate the roles in familiarity discrimination of the three main subtypes of ionotropic glutamate receptors; AMPA, NMDA (including NR2A and NR2B subunits), and kainate. Their roles were sought via direct infusions into rat perirhinal cortex. Recognition memory was assessed using a test that exploits the spontaneous preference of rats to explore novel stimuli. Animals were presented with two identical objects and, following a delay of 20 min or 24 h, the time spent exploring the familiar and a novel object was measured. Infusions of CNQX (AMPA/kainate selective) impaired the acquisition of both shorter (20 min) and longer (24 h) term recognition memory. Infusions of AP5 (NMDA selective) impaired the acquisition of longer term (24 h) but not shorter term (20 min) recognition memory. Infusions of NVP-AAM077 (NMDA subunit NR2A selective) or Ro25-6981 (NMDA subunit NR2B selective) did not impair recognition memory at either time point; however, when both were infused together recognition memory was impaired at the 24 h but not the 20 min delay, as for AP5. In contrast, infusion of UBP302 (kainate GluR5 subunit selective) produced a most unusual, opposite impairment of recognition memory, namely amnesia after a delay of 20 min but normal performance after a delay of 24 h. The results establish that more than one mechanism underlies perirhinal familiarity discrimination: an NMDA-receptor dependent mechanism necessary for longer-term memory and a kainate-receptor dependent mechanism necessary for shorter-term memory.
UBP302 was kindly supplied by Dr DE Jane, University of Bristol.
UBP302 was kindly supplied by Dr DE Jane, University of Bristol.
Supported by MRC
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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