Neuroscience 2001 Abstract
| Presentation Number: | 886.9 |
|---|---|
| Abstract Title: | Neural Activity Changes Associated with Visual Learning, Schizophrenic and Normal Responses Assessed with Single Event Functional MRI. |
| Authors: |
Holcomb, H. H.*1
; Beason-Held, L.1
; Kakoyannis, A.1
; Puri, R.1
; Nepomuceno, M.1
; Tagamets, M. A.1
; Ma, N.1
1Maryland Psychiatric Res Ctr, Univ Maryland, Baltimore, MD |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Psychiatric Disorders -- Schizophrenia |
| Secondary Theme and Topics | Cognition and Behavior<br />- Human Cognition and Behavior<br />-- Learning and memory |
| Session: |
886. Psychiatric disorders: schizophrenia--psychology and imaging Slide |
| Presentation Time: | Thursday, November 15, 2001 10:00 AM-10:15 AM |
| Location: | Room 5B |
| Keywords: | plasticity, accuracy, recognition, memory |
Present learning theories endorse the importance of synaptic plasticity; experience with a stimulus, problem, or procedure is associated with the progressive diminution in synaptic activity across most connections but increased synaptic efficiency across those that are most relevant for behavioral success. Persons with schizophrenia (SZ) may differ from normal volunteers (NV) by virtue of their inability to enhance synaptic efficiency at critical sites during learning. This visual learning study was designed to assess the ways in which SZ and NV differ in their neural response to visual recognition training.
NV (n=6, mean age=29) and SZ (n=6, mean age=35) participated in two event-related functional magnetic resonance imaging studies (er_fMRI). The first was obtained prior to training and the second following completion of four training sessions. The task used a 6 second delay between the onset of the first and second stimulus (black rectangle within a frame) to assess hemodynamic response functions during encoding and retrieval phases of the stimulus matching task (same or different block height). Task difficulty was manipulated to render SZ and NV performances similar. ER_fMRI was analyzed with SPM99 software to provide individual and group analyses.
Whereas four out of six NV exhibited marked activation reductions in the second ER_fMRI study, only two SZ showed reductions. Importantly, half of the SZ exhibited activity elevations during the second study (no NV showed this pattern). These preliminary data are consistent with aberrant plasticity functions in SZ cortex during learning.
NV (n=6, mean age=29) and SZ (n=6, mean age=35) participated in two event-related functional magnetic resonance imaging studies (er_fMRI). The first was obtained prior to training and the second following completion of four training sessions. The task used a 6 second delay between the onset of the first and second stimulus (black rectangle within a frame) to assess hemodynamic response functions during encoding and retrieval phases of the stimulus matching task (same or different block height). Task difficulty was manipulated to render SZ and NV performances similar. ER_fMRI was analyzed with SPM99 software to provide individual and group analyses.
Whereas four out of six NV exhibited marked activation reductions in the second ER_fMRI study, only two SZ showed reductions. Importantly, half of the SZ exhibited activity elevations during the second study (no NV showed this pattern). These preliminary data are consistent with aberrant plasticity functions in SZ cortex during learning.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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