Neuroscience 2001 Abstract
| Presentation Number: | 886.6 |
|---|---|
| Abstract Title: | A Structural and Functional MRI Study of the Motor System in Schizophrenia. |
| Authors: |
Kotrla, K. J.*1
; Baucom, C. C.2
; Langdoc, J.1
; Diaz, P.1
; Corey, D. M.2
; Lemen, L. C.3
; Van Gelderen, P.4
; Cusick, C. G.2
; Foundas, A. L.2
1Baylor College of Medicine, Houston, TX 2Tulane University HSC, New Orleans, LA 3Louisiana State HSC, New Orleans, LA 4National Institutes of Health, Bethesda, MD |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Psychiatric Disorders -- Schizophrenia |
| Session: |
886. Psychiatric disorders: schizophrenia--psychology and imaging Slide |
| Presentation Time: | Thursday, November 15, 2001 9:15 AM-9:30 AM |
| Location: | Room 5B |
| Keywords: | schizophrenia, functional MRI, neuroimaging, motor cortex |
Distributed brain abnormalities are associated with schizophrenia. Psychoticism, disorganization, and negative symptoms are independent symptom complexes in schizophrenia; how specific neural networks are associated with these domains is unclear. By studying individuals with paranoid schizophrenia, we investigated whether dysfunction in the psychoticism domain involves even basic motor systems.
Twelve males with paranoid schizophrenia were compared to 12 age, gender, and handedness matched controls. Structural T1 weighted MRI scans were acquired in a 1.5T GE scanner producing 1.5 mm continguous slices through the whole brain. Total brain volume and discrete cortical regions were measured using NIHImage. There was no significant difference in total brain volume or central sulcus length in schizophrenia. However, paranoid schizophrenia was associated with significantly larger motor knobs bilaterally (p<0.02). This finding held even when normalized to total brain volume (p<0.04).
Moreover, 7 individuals with paranoid schizophrenia and 10 normal controls were imaged as they moved the fingers of their dominant hand against their thumb in a self-paced sequence using PRESTO to obtain 24 slices of functional data. Movement lasted for 30 seconds, followed by 30 seconds of rest. Despite a larger volume of the motor knob, individuals with schizophrenia showed reduced activation during the task. This suggests localized abnormalities in the motor system in individuals with paranoid schizophrenia.
Twelve males with paranoid schizophrenia were compared to 12 age, gender, and handedness matched controls. Structural T1 weighted MRI scans were acquired in a 1.5T GE scanner producing 1.5 mm continguous slices through the whole brain. Total brain volume and discrete cortical regions were measured using NIHImage. There was no significant difference in total brain volume or central sulcus length in schizophrenia. However, paranoid schizophrenia was associated with significantly larger motor knobs bilaterally (p<0.02). This finding held even when normalized to total brain volume (p<0.04).
Moreover, 7 individuals with paranoid schizophrenia and 10 normal controls were imaged as they moved the fingers of their dominant hand against their thumb in a self-paced sequence using PRESTO to obtain 24 slices of functional data. Movement lasted for 30 seconds, followed by 30 seconds of rest. Despite a larger volume of the motor knob, individuals with schizophrenia showed reduced activation during the task. This suggests localized abnormalities in the motor system in individuals with paranoid schizophrenia.
Supported by NARSAD, South Central MIRECC
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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