Neuroscience 2005 Abstract
| Presentation Number: | 828.7 |
|---|---|
| Abstract Title: | Behaviorally disruptive doses of δ-9-tetrahydrocannabinol do not affect cell proliferation in the adult mouse dentate gyrus. |
| Authors: |
Kochman, L. J.*1
; Amancio-dos-Santos, A.
; Fornal, C. A.1
; Jacobs, B. L.1
1Program in Neuroscience, Princeton Univ., Princeton, NJ |
| Primary Theme and Topics |
Development - Neurogenesis and Gliogenesis -- Proliferation |
| Secondary Theme and Topics | Disorders of the Nervous System<br />- Addiction and Drugs of Abuse<br />-- Cannabinoids |
| Session: |
828. Adult Neurogenesis Modulated by Drugs, Stress, and Hormones Poster |
| Presentation Time: | Wednesday, November 16, 2005 10:00 AM-11:00 AM |
| Location: | Washington Convention Center - Hall A-C, Board # B47 |
| Keywords: | BRDU, CANNABINOIDS, HIPPOCAMPUS, NEUROGENESIS |
Marijuana is one of the most widely abused illicit drugs and is known to cause significant cognitive impairments. It has been hypothesized that marijuana may preferentially target neurons in the hippocampus because of the abundance of cannabinoid receptors present in this structure. While there is no clear evidence of neuropathology in vivo, suppression of brain mitogenesis, and ultimately neurogenesis, may provide a sensitive index of marijuana’s more subtle effects on neural mechanisms subserving cognitive functions. To this end, we examined the effects of different doses and treatment regimens (both acute and chronic) of delta-9-tetrahydrocannabinol (THC), the main active ingredient in marijuana, on cell proliferation in the mouse dentate gyrus (DG), using the bromodeoxyuridine method (BrdU; 200 mg/kg, i.p; 2 h survival time). Administration of THC produced marked dose- and time-dependent behavioral sedation and catalepsy. The number of BrdU labeled cells was not significantly changed from vehicle control levels following either acute, both single (1, 3, 10, 30 mg/kg, i.p.) and multiple (two injections of 10 or 30 mg/kg, i.p., separated by 5 h) administration, or chronic treatment (20, 40, 80 mg/kg, p.o.; daily doses escalated weekly for 3 weeks). Furthermore, the potent synthetic cannabinoid receptor agonist WIN 55,212-2 (WIN; 5 mg/kg, i.p.) also had no significant effect on cell proliferation when given acutely (2 injections). These findings provide no evidence for suppression of hippocampal cell proliferation by THC (or WIN), despite gross behavioral intoxication. The question as to whether marijuana or THC affects neurogenesis still remains to be explored.
Supported by DA016976, CNPq 200924/03-6(NV)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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