Neuroscience 2000 Abstract
| Presentation Number: | 872.13 |
|---|---|
| Abstract Title: | MRI-volumetric study of major lobes and gyri of the human cerebrum: automated gray-white segmentation and anatomically based parcellation. |
| Authors: |
Allen, J. S.*1
; Damasio, H.1
; Grabowski, T. J.1
; Tranel, D.1
; Cole, J.1
1Dept. of Neurology, University of Iowa College of Medicine, Iowa City, IA |
| Primary Theme and Topics |
J. Disorders of the Nervous System and Aging - 148. Aging |
| Secondary Theme and Topics | G. Motor Systems and Sensorimotor Integration<br />- 86. Cortex and thalamus |
| Session: |
872. Aging V Poster |
| Presentation Time: | Thursday, November 9, 2000 8:00 AM-9:00 AM |
| Location: | Hall G-J |
| Keywords: | imaging, neuroanatomy, cortex, volumetry |
The quantitative distribution of gray and white matter in the human brain is not well established. Recent MRI-based studies have provided gray-white (G/W) measurements over large sectors of the brain, or have been based on sampling methods over smaller and arbitrarily defined regions. We report on a study of the gray-white volumes of the major lobes and gyri of the human cerebrum. Regions of interest were identified using neuroanatomical surface landmarks on 3D reconstructions of T1-weighted contiguous MR coronal slices through the whole brain (1.5-1.6mm thick; 110-120 slices per brain). The following lobes were manually traced separately for left and right hemispheres: frontal, parietal, temporal, occipital. Gyri traced included the cingulate, insula, and all the major gyri of the frontal, parietal, and temporal lobes. The MRI data were segmented into gray-white-CSF using an automated algorithm, which was capable of generating fractionally classified voxels. Subjects were 23 men (22-49 years, mean=32.1, s.d.=8.8) and 23 women (23-47 years, mean=32.6, s.d.=7.5). All were right-handed, healthy, and without neurological or psychiatric disease. Results pertaining to the major lobes, cingulate, and insula were as follows: (1) G/W ratios vary across different brain structures; from highest to lowest: insula>cingulate>temporal/occipital>frontal>parietal; (2) G/W ratio is not strongly correlated with volume; (3) the proportional representation of the lobes/gyri within the cerebrum exhibits relatively little variation; (4) in males, the left cingulate is significantly larger than the right; (5) males have significantly larger frontal, temporal, and parietal lobes, and insula; females have higher G/W ratios for every structure and a higher ratio for the whole cerebrum. This survey, the most comprehensive of its kind to date, provides valuable normative data regarding human brain volumes and G/W ratios. (NINDS PO1 NS19632).
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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