Neuroscience 2004 Abstract
| Presentation Number: | 815 |
|---|---|
| Abstract Title: | Endocannabinoids and synaptic plasticity. |
| Authors: |
Melis, M.*
; Brenowitz, S.
; Castillo, P. E.1
; Gerdeman, G. L.
; Marsicano, G.
; Manzoni, O. J.
1Neurosci, Albert Einstein Col.Med, Bronx, NY |
| Primary Theme and Topics |
Synaptic Transmission and Excitability - Synaptic Plasticity -- Other |
| Session: |
815. Minisymposium: Endocannabinoids and Synaptic Plasticity Mini-Symposium |
| Presentation Time: | Wednesday, October 27, 2004 8:30 AM-11:00 AM |
| Location: | San Diego Convention Center - Room 31C |
| Keywords: | CANNABINOIDS, GABA GLUTAMATE, DRUG ABUSE, LTD LTP |
Endocannabinoids are endogenous lipid molecules that act as retrograde messengers at many synapses in the central nervous system, by binding to presynaptic cannabinoid receptors (CB1Rs) and inhibiting neurotransmitter release. The CB1R is one of the most abundant G-protein-coupled receptors in the brain, and mediates most of the behavioral actions of THC, the active principle of Cannabis sativa. Although the existence of an endogenous cannabinoid signaling system is well established, its physiological role is just beginning to be understood. Speakers will discuss the functional impact of endocannabinoids in diverse brain structures, focusing on recent advances on the role of these retrograde messengers in synaptic plasticity. M. Melis will present her recent data on the effects of endocannabinoids in regulating glutamate and GABA release in the ventral tegmental area. S. Brenowitz will discuss a novel form of associative plasticity at cerebellar synapses that is mediated by endocannabinoids. P.E. Castillo will talk about the role of endocannabinoids in the hippocampus as mediators of long-term synaptic plasticity at inhibitory synapses, and metaplasticity at excitatory synapses. G.L. Gerdeman will discuss evidence that a postsynaptic membrane transporter can regulate endocannabinoid-mediated synaptic plasticity in the striatum. G. Marsicano will describe his recent results on the role of endocannabinoids in organizing aversive behaviors, discovered by using conditional mutant mice lacking CB1Rs in specific neuronal subpopulations. Finally, O.J. Manzoni will focus on the nucleus accumbens and how in vivo exposure to addictive drugs can modify retrograde endocannabinoid signaling in this key area of the brain reward system.
8:30 815.1 Endocannabinoid-mediated Retrograde Signaling in the Ventral Tegmental Area. M. MELIS, Univ. of Cagliari.
8:55 815.2 Associative Short-term Plasticity Mediated by Endocannabinoids. S.D. BRENOWITZ, Harvard Med. Sch.
9:20 815.3 Transynaptic Dialogue Between Excitation and Inhibition Mediated by Endocannabinoids. P.E. CASTILLO, Albert Einstein Col. of Med.
9:45 815.4 Endocannabinoid Membrane Transport During Induction of Striatal Long-term Depression. G.L. GERDEMAN, Univ. of Arizona.
10:10 815.5 Coping with Aversive Situations: The Roles of the Endocannabinoid System. G. MARSICANO, Max-Planck-Inst. of Psychiatry.
10:35 815.6 Endocannabinoid-mediated Long-term Synaptic Plasticity in the Nucleus Accumbens: Regulation by Addictive Drugs. O. MANZONI, Magendie Inst.
8:30 815.1 Endocannabinoid-mediated Retrograde Signaling in the Ventral Tegmental Area. M. MELIS, Univ. of Cagliari.
8:55 815.2 Associative Short-term Plasticity Mediated by Endocannabinoids. S.D. BRENOWITZ, Harvard Med. Sch.
9:20 815.3 Transynaptic Dialogue Between Excitation and Inhibition Mediated by Endocannabinoids. P.E. CASTILLO, Albert Einstein Col. of Med.
9:45 815.4 Endocannabinoid Membrane Transport During Induction of Striatal Long-term Depression. G.L. GERDEMAN, Univ. of Arizona.
10:10 815.5 Coping with Aversive Situations: The Roles of the Endocannabinoid System. G. MARSICANO, Max-Planck-Inst. of Psychiatry.
10:35 815.6 Endocannabinoid-mediated Long-term Synaptic Plasticity in the Nucleus Accumbens: Regulation by Addictive Drugs. O. MANZONI, Magendie Inst.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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