Neuroscience 2001 Abstract
| Presentation Number: | 877.1 |
|---|---|
| Abstract Title: | QUANTITATIVE MAGNETIC RESONANCE IMAGING (MRI) AND PROTON MAGNETIC RESONANCE SPECTROSCOPIC IMAGING (MRSI) OF DORSOLATERAL PREFRONTAL CORTEX IN CHILDREN WITH FETAL ALCOHOL SYNDROME. |
| Authors: |
Cortese, B. M.*1
; Hannigan, J. H.2
; Moore, G. J.1
1Brain Imaging Res Div, Psych/Behav Neurosci, Wayne State Univ. Sch. of Med., Detroit, MI 2OB/GYN, Wayne State Univ. Sch. of Med., Detroit, MI |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Addiction and Drugs of Abuse -- Alcohol, barbituates, and benzodiazepines |
| Session: |
877. Addiction and drugs of abuse: alcohol--perinatal and adolescent exposure Poster |
| Presentation Time: | Wednesday, November 14, 2001 1:00 PM-2:00 PM |
| Location: | Exhibit Hall ZZ-46 |
| Keywords: | CNS, ALCOHOL, BRAIN IMAGING, NEOCORTEX |
MR Imaging techniques (volumetric MRI and MRSI) are a non-invasive way to assess neuroanatomy and neurochemistry in humans by measuring brain volumes and CNS levels of certain neurochemicals, esp. the neuron-specific N-acetyl-aspartate (NAA). The present study sought to quantify the absolute value of [NAA] and volume of the dorsolateral prefrontal cortex in children diagnosed with FAS (n=5; 7 to 10 yrs; 1 boy/4 girls) as compared to historical controls (n=5; 9 to 12 yrs; 1 boy/4 girls), using a 1.5-T General Electric Signa scanner (Horizon hardware, 5.7 software). Gray matter volumes in both left and right dorsolateral prefrontal neocortex were significantly decreased in the FAS subjects compared to controls (p's<0.02). In the FAS subjects, the absolute values of [NAA] in left and right dorsolateral prefrontal neocortex were decreased 20% (left) and 16% (right) from controls. The results of the present study demonstrate significant decreases in the size and decreased neuronal functioning (i.e., reduced [NAA]) of the dorsolateral prefrontal cortex in FAS. These results are also consistent with prior research by others (e.g., Mattson, et al., 1999) demonstrating executive dysfunction in children with FAS, for example, problems with working memory, attentional shifting and planning. Such executive functions are known to be disrupted by damage to the dorsolateral prefrontal neocortex.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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