Neuroscience 2004 Abstract
|Abstract Title:||Reduction of the conditioned locomotor response following NMDA-induced lesions of the infralimbic cortex in rats sensitized to the dopamine agonist quinpirole.|
Ray, L. B.*1
; Szechtman, H.1
1Psychiatry & Behvaioural Neurosci., McMaster Univ, Hamilton, Canada
|Primary Theme and Topics||
Neurological and Psychiatric Conditions
- Behavioral Pharmacology
807. Monoamines II
|Presentation Time:||Tuesday, October 26, 2004 1:00 PM-2:00 PM|
|Location:||San Diego Convention Center - Hall A-H, Board # FFF8|
|Keywords:||PSYCHOSTIMULANT DRUGS, D2/D3 RECEPTOR, MEDIAL PREFRONTAL CORTEX, SENSITIZATION|
Male rats received bi-weekly injections of QNP (0.5mg/kg sc x 10) or saline (SAL) and their locomotor activity monitored after each injection for 55 min on a large open-field (160 x 160 cm). Subsequently, rats underwent IPC neurotoxic lesions using NMDA (20mg/mL) or sham operations. After a one-week recovery period, rats received another injection of QNP or SAL to measure lesion effects on the expression of sensitization. The twelfth injection was the test for conditioned locomotor activity and all animals were administered SAL. Although currently based on a small sample size (N=6/group), results indicated that IPC lesions did not affect the expression of sensitized locomotion induced by QNP. However, IPC-lesion animals sensitized to QNP did show a significant reduction in the expression of conditioned locomotor activity compared to sham QNP-sensitized rats. No change in locomotor activity was identified in IPC-lesion animals that received chronic SAL injections. Results suggest that the expression of a conditioned locomotor response to QNP may be mediated by neurotransmission in the IPC.
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